Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases

Details

• Alternative Title:
  Lancet Infect Dis
• Personal Author:
  Munoz-Price, L Silvia ; Poirel, Laurent ; Bonomo, Robert A ; Schwaber, Mitchell J ; Daikos, George L ; Cormican, Martin ; Cornaglia, Giuseppe ; Garau, Javier ; Gniadkowski, Marek ; Hayden, Mary K ; Kumarasamy, Karthikeyan ; Livermore, David M ; Maya, Juan J ; Nordmann, Patrice ; Patel, Jean B ; Paterson, David L ; Pitout, Johann ; Villegas, Maria Virginia ; Wang, Hui ; Woodford, Neil ; Quinn, John P
• Description:
  Klebsiella pneumoniae carbapenemases (KPCs) were originally identified in the USA in 1996. Since then, these versatile β-lactamases have spread internationally among Gram-negative bacteria, especially K pneumoniae, although their precise epidemiology is diverse across countries and regions. The mortality described among patients infected with organisms positive for KPC is high, perhaps as a result of the limited antibiotic options remaining (often colistin, tigecycline, or aminoglycosides). Triple drug combinations using colistin, tigecycline, and imipenem have recently been associated with improved survival among patients with bacteraemia. In this Review, we summarise the epidemiology of KPCs across continents, and discuss issues around detection, present antibiotic options and those in development, treatment outcome and mortality, and infection control. In view of the limitations of present treatments and the paucity of new drugs in the pipeline, infection control must be our primary defence for now.
• Subjects:
  Aminoglycosides Anti-Bacterial Agents Article Bacteremia Bacterial Proteins Beta-Lactamases Colistin Communicable Disease Control Geography Humans Klebsiella Infections Klebsiella Pneumoniae Minocycline Tigecycline Treatment Outcome

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• Source:
  Lancet Infect Dis. 13(9):785-796
• Pubmed ID:
  23969216
• Pubmed Central ID:
  PMC4673667
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States
• Place as Subject:
  United States
• Volume:
  13
• Issue:
  9
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:9c5cc6ad3290704f4aa9c621c01aba3d35b93ccdf78cc76e25f62f48ac7f1d3b
• Download URL:
  https://stacks.cdc.gov/view/cdc/36780/cdc_36780_DS1.pdf
• File Type:
  [PDF - 494.34 KB ]