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Evaluating Endocrine Disruption Activity of Deposits on Firefighting Gear Using a Sensitive & High Throughput Screening Method
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Evaluating Endocrine Disruption Activity of Deposits on Firefighting Gear Using a Sensitive & High Throughput Screening Method
Details:
  • Pubmed ID:
    26641839
  • Pubmed Central ID:
    PMC4672464
  • Funding:
    P30 ES006096/ES/NIEHS NIH HHS/United States
    T42 OH008432/OH/NIOSH CDC HHS/United States
    ES006096/ES/NIEHS NIH HHS/United States
    T42/OH008732-06/OH/NIOSH CDC HHS/United States
  • Document Type:
  • Collection(s):
  • Description:
    Objective

    Adverse health outcomes related to exposure to endocrine disrupting chemicals (EDCs), including increased incidences of coronary heart disease, prostate and testicular cancers, and birth defects have been reported in firefighters or their offspring. We, therefore, measured the estrogenic and antiestrogenic activity of extracts of used firefighter gear to assess exposure to these agents.

    Methods

    Extracts and known chemical contaminants were examined for estrogenicity and antiestrogenicity in yeast cells expressing the estrogen receptor.

    Results

    Most extracts of used gear, and phthalate diesters detectable on this gear displayed strong antiestrogenic effects. Notably, new glove and hood extracts showed significant estrogenic activity.

    Conclusions

    Overall, our data suggest that firefighters are exposed to both estrogenic and antiestrogenic agents, possibly phthalates that may lead to health risks observed in this occupation as a result of perturbation of hormone homeostasis.