Details:

Alternative Title:
J Nanomater
Publisher's site:
http://dx.doi.org/10.1155/2012/398302
Personal Author:
Roberts, Jenny R. ; Mercer, Robert R. ; Chapman, Rebecca S. ; Cohen, Guy M. ; Bangsaruntip, Sarunya ; ... More +
Roberts, Jenny R. ; Mercer, Robert R. ; Chapman, Rebecca S. ; Cohen, Guy M. ; Bangsaruntip, Sarunya ; Schwegler-Berry, Diane ; Scabilloni, James F. ; Castranova, Vincent ; Antonini, James M. ; Leonard, Stephen S. Less -
Description:
Silicon nanowires (Si NWs) are being manufactured for use as sensors and transistors for circuit applications. The goal was to assess pulmonary toxicity and fate of Si NW using an in vivo experimental model. Male Sprague-Dawley rats were intratracheally instilled with 10, 25, 50, 100, or 250 μg of Si NW (~20-30 nm diameter; ~2-15 μm length). Lung damage and the pulmonary distribution and clearance of Si NW were assessed at 1, 3, 7, 28, and 91 days after-treatment. Si NW treatment resulted in dose-dependent increases in lung injury and inflammation that resolved over time. At day 91 after treatment with the highest doses, lung collagen was increased. Approximately 70% of deposited Si NW was cleared by 28 days with most of the Si NW localized exclusively in macrophages. In conclusion, Si NW induced transient lung toxicity which may be associated with an early rapid particle clearance; however, persistence of Si NW over time related to dose or wire length may lead to increased collagen deposition in the lung.
Subjects:
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Article
Source:
J Nanomater. 2012.
Pubmed ID:
26640479
Pubmed Central ID:
PMC4668952
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:5425d1bc2252bbe704489bbf75977f5c16bf3086ecf63106bd21f5a962ac32ca
Download URL:
https://stacks.cdc.gov/view/cdc/36748/cdc_36748_DS1.pdf
File Type:

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