Serologic evidence of human orthopoxvirus infections in Sierra Leone

MacNeil, Adam; Abel, Jason; Reynolds, Mary G; Lash, RR; Fonnie, Richard; Kanneh, Lansana D; Robert, Willie; Lungay, Victor K; Goba, Augustine; Moses, Lina M; Damon, Inger K; Karem, Kevin; Bausch, Daniel G

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Serologic evidence of human orthopoxvirus infections in Sierra Leone

Published Date:

Oct 28 2011

Source:

BMC Res Notes. 2011; 4:465.

[PDF-549.18 KB]

Details:

Alternative Title:

BMC Res Notes

Personal Author:

MacNeil, Adam ; Abel, Jason ; Reynolds, Mary G ; Lash, RR ; Fonnie, Richard ; ... More ▼

Description:

Background

Orthopoxviruses, including variola virus, vaccinia virus, and monkeypox virus, have previously been documented in humans in West Africa, however, no cases of human orthopoxvirus infection have been reported in the region since 1986. We conducted a serosurvey to determine whether human exposure to orthopoxviruses continues to occur in eastern Sierra Leone.

Findings

To examine evidence of exposure to orthopoxviruses in the Kenema District of Sierra Leone, we collected and tested sera from 1596 persons by IgG ELISA and a subset of 313 by IgM capture ELISA. Eleven persons born after the cessation of smallpox vaccination had high orthopoxvirus-specific IgG values, and an additional 6 persons had positive IgM responses. No geographic clustering was noted.

Conclusions

These data suggest that orthopoxviruses continue to circulate in Sierra Leone. Studies aimed at obtaining orthopoxvirus isolates and/or genetic sequences from rodents and symptomatic humans in the area are indicated.

Subject:

[+]

Document Type:

Journal Article

Collection(s):

CDC Public Access

Main Document Checksum:

[+]

Supporting Files:

	license.txt	text/plain
	1756-0500-4-465-1.gif	image/gif
	1756-0500-4-465-1.jpg	image/jpeg
	1756-0500-4-465-2.gif	image/gif
	1756-0500-4-465-2.jpg	image/jpeg
	1756-0500-4-465-3.gif	image/gif
	1756-0500-4-465-3.jpg	image/jpeg
	1756-0500-4-465.nxml	text/plain

No Related Documents.

You May Also Like:

Human Monkeypox in Sierra Leone after 44-Year Absence of Reported Cases

Personal Author:

Reynolds, Mary G.; Wauquier, Nadia; Li, Yu; Satheshkumar, Panayampalli Subbian; Kanneh, Lansana D.; Monroe, Benjamin; Maikere, Jacob; Saffa, Gbessay; Gonzalez, Jean-Paul; Fair, Joseph; Carroll, Darin S.; Jambai, Amara; Dafae, Foday; Khan, Sheik Humarr; Moses, Lina M.;

Published Date:

May 17 2019

Source:

Emerg Infect Dis. 25(5):1023-1025

Description:

We note the reemergence of human monkeypox in Sierra Leone following a 44-year absence of reported disease. The persons affected were an 11-month-old boy and, several years later, a 35-year-old man. The reappearance of monkeypox in this country sugge...

File Type:

[PDF - 523.43 KB]
A Silent Enzootic of an Orthopoxvirus in Ghana, West Africa: Evidence for Multi-Species Involvement in the Absence of Widespread Human Disease

Personal Author:

Reynolds, Mary G.; Carroll, Darin S.; Olson, Victoria A.; Hughes, Christine; Galley, Jack; Likos, Anna; Montgomery, Joel M.; Suu-Ire, Richard; Kwasi, Mubarak O.; Jeffrey Root, J.; Braden, Zach; Abel, Jason; Clemmons, Cody; Regnery, Russell; Karem, Kevin; Damon, Inger K.;

Published Date:

Apr 2010

Source:

Am J Trop Med Hyg. 2010; 82(4):746-754.

Description:

Human monkeypox has never been reported in Ghana, but rodents captured in forested areas of southern Ghana were the source of the monkeypox virus introduced into the United States in 2003. Subsequent to the outbreak in the United States, 204 animals ...

File Type:

[PDF - 743.61 KB]
Evaluation of the GeneXpert for Human Monkeypox Diagnosis

Personal Author:

Li, Daniel; Wilkins, Kimberly; McCollum, Andrea M.; Osadebe, Lynda; Kabamba, Joelle; Nguete, Beatrice; Likafi, Toutou; Balilo, Marcel Pie; Lushima, Robert Shongo; Malekani, Jean; Damon, Inger K.; Vickery, Michael C. L.; Pukuta, Elisabeth; Nkawa, Frida; Karhemere, Stomy; Tamfum, Jean-Jacques Muyembe; Okitolonda, Emile Wemakoy; Li, Yu; Reynolds, Mary G.;

Published Date:

Dec 19 2016

Source:

Am J Trop Med Hyg. 2017; 96(2):405-410.

Description:

Monkeypox virus (MPXV), a zoonotic orthopoxvirus (OPX), is endemic in the Democratic Republic of Congo (DRC). Currently, diagnostic assays for human monkeypox (MPX) focus on real-time quantitative polymerase chain reaction (PCR) assays, which are typ...

File Type:

[PDF - 574.81 KB]
Hepatic Brucelloma Diagnosis and Long-Term Treatment, France

Personal Author:

Amsilli, Marie; Epaulard, Olivier; Brion, Jean-Paul; Pavese, Patricia; Letoublon, Christian; Pelloux, Isabelle; Maurin, Max;

Published Date:

May 2019

Source:

Emerg Infect Dis. 25(5):1021-1023

Description:

We report a case of hepatic brucelloma in France. This diagnosis may be suspected in any patient who has a liver abscess after traveling to a brucellosis-endemic area. Brucella spp. may be detected by PCR in the liver tissue or suppuration. Abscess d...

File Type:

[PDF - 360.40 KB]
Molecular Evidence of Human Monkeypox Virus Infection, Sierra Leone

Personal Author:

Ye, Fei; Song, Jingdong; Zhao, Li; Zhang, Yi; Xia, Lianxu; Zhu, Lingwei; Kamara, Idrissa Laybohr; Ren, Jiao; Wang, Wenling; Tian, Houwen; Wu, Guizhen; Tan, Wenjie;

Published Date:

June 17 2019

Source:

Emerg Infect Dis. 25(6):1220-1222

Description:

Monkeypox virus is a zoonotic disease endemic to Africa. In 2017, we confirmed a case of human monkeypox virus in Sierra Leone by molecular and serologic methods. Sequencing analysis indicated the virus belongs to the West African clade and data sugg...

File Type:

[PDF - 452.60 KB]