Details:

Alternative Title:
BMC Res Notes
Personal Author:
MacNeil, Adam ; Abel, Jason ; Reynolds, Mary G ; Lash, RR ; Fonnie, Richard ; ... More +
MacNeil, Adam ; Abel, Jason ; Reynolds, Mary G ; Lash, RR ; Fonnie, Richard ; Kanneh, Lansana D ; Robert, Willie ; Lungay, Victor K ; Goba, Augustine ; Moses, Lina M ; Damon, Inger K ; Karem, Kevin ; Bausch, Daniel G Less -
Description:
Background

Orthopoxviruses, including variola virus, vaccinia virus, and monkeypox virus, have previously been documented in humans in West Africa, however, no cases of human orthopoxvirus infection have been reported in the region since 1986. We conducted a serosurvey to determine whether human exposure to orthopoxviruses continues to occur in eastern Sierra Leone.

Findings

To examine evidence of exposure to orthopoxviruses in the Kenema District of Sierra Leone, we collected and tested sera from 1596 persons by IgG ELISA and a subset of 313 by IgM capture ELISA. Eleven persons born after the cessation of smallpox vaccination had high orthopoxvirus-specific IgG values, and an additional 6 persons had positive IgM responses. No geographic clustering was noted.

Conclusions

These data suggest that orthopoxviruses continue to circulate in Sierra Leone. Studies aimed at obtaining orthopoxvirus isolates and/or genetic sequences from rodents and symptomatic humans in the area are indicated.


Subjects:
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Short Report
Source:
BMC Res Notes. 2011; 4:465.
Document Type:
Journal Article
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:2d9b19f9aab5f03c7fcdaea0fae13914875b7568286836f70c7265fb23ee44f2
Download URL:
https://stacks.cdc.gov/view/cdc/3673/cdc_3673_DS1.pdf
File Type:

Supporting Files

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