Details:

Alternative Title:
Trans R Soc Trop Med Hyg
Personal Author:
Staples, J. Erin ; Diallo, Mawlouth ; Janusz, Kristen B. ; Manengu, Casimir ; Lewis, Rosamund F. ; ... More +
Staples, J. Erin ; Diallo, Mawlouth ; Janusz, Kristen B. ; Manengu, Casimir ; Lewis, Rosamund F. ; Perea, William ; Yactayo, Sergio ; Sall, Amadou A. Less -
Description:
Background

Starting in 2008, the Central African Republic (CAR) experienced an unprecedented number of reported yellow fever (YF) cases. A risk assessment of YF virus (YFV) activity was conducted to estimate potential disease risk and vaccine needs.

Methods

A multistage cluster sampling design was used to sample humans, non-human primates, and mosquitoes in distinct ecologic zones. Humans and non-human primates were tested for YFV-specific antibodies; mosquitoes were tested for YFV RNA.

Results

Overall, 13.3% (125/938) of humans were found to have naturally-acquired YFV antibodies. Antibody levels were higher in zones in the southern and south central regions of CAR. All sampled non-human primates (n=56) were known YFV reservoirs; one tested positive for YFV antibodies. Several known YF vectors were identified including Aedes africanus, Ae. aegypti, Ae. luteocephalus, and Ae. simpsoni. Several more urban locations were found to have elevated Breateau and Container indices for Ae. aegypti.

Conclusions

A country-wide assessment of YF risk found YFV to be endemic in CAR. The potential for future YF cases and outbreaks, however, varied by ecologic zone. Improved vaccination coverage through mass campaign and childhood immunization was recommended to mitigate the YF risk.


Subject:
[+]
Aedes
Animals
Antibodies, Viral
Article
Cluster Analysis
Humans
Insect Vectors
Population Surveillance
Primate Diseases
Primates
Risk Assessment
RNA, Viral
Yellow Fever

Source:
Trans R Soc Trop Med Hyg. 108(10):608-615.
Pubmed ID:
24947520
Pubmed Central ID:
PMC4653062
Document Type:
Journal Article
Funding:
001/World Health Organization/International ; CC999999/Intramural CDC HHS/United States
001/World Health Organization/International ; CC999999/Intramural CDC HHS/United States Less -
Place as Subject:
Central African Republic
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:578f1c637513315b5dfed132a86cc61f3e5895f1c8db2e6ad8d707023d690ffb
File Type:

Supporting Files

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