Details:

Alternative Title:
Nanotoxicology
Publisher's site:
http://dx.doi.org/10.3109/17435390.2013.796536
Personal Author:
Kan, Hong ; Wu, Zhongxin ; Lin, Yen-Chang ; Chen, Teh-Hsun ; Cumpston, Jared L ; ... More +
Kan, Hong ; Wu, Zhongxin ; Lin, Yen-Chang ; Chen, Teh-Hsun ; Cumpston, Jared L ; Kashon, Michael L ; Leonard, Steve ; Munson, Albert E ; Castranova, Vincent Less -
Description:
The inhalation of nanosized air pollutant particles is a recognised risk factor for cardiovascular disease; however, the link between occupational exposure to engineered nanoparticles and adverse cardiovascular events remains unclear. In the present study, the authors demonstrated that pulmonary exposure of rats to ultrafine titanium dioxide (UFTiO2) significantly increased heart rate and depressed diastolic function of the heart in response to isoproterenol. Moreover, pulmonary inhalation of UFTiO2 elevated mean and diastolic blood pressure in response to norepinephrine. Pretreatment of the rats ip with the transient receptor potential (TRP) channel blocker ruthenium red inhibited substance P synthesis in nodose ganglia and associated functional and biological changes in the cardiovascular system. In conclusion, the effects of pulmonary inhalation of UFTiO2 on cardiovascular function are most likely triggered by a lung-nodose ganglia-regulated pathway via the activation of TRP channels in the lung.
Subject:
[+]
Administration, Inhalation
Analysis Of Variance
Animals
Article
Blood Pressure
Cardiovascular System
Ganglia, Spinal
Heart Rate
Inhalation Study
Male
Myocardium
Myocytes, Cardiac
Nanoparticles
Neural Pathways
Nodose Ganglion
Rats
Rats, Sprague-Dawley
Reactive Oxygen Species
Substance P
Titanium
Troponin I
Ventricular Function, Left

Source:
Nanotoxicology. 8(4):447-454.
Pubmed ID:
23593933
Pubmed Central ID:
PMC4652323
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:9a165f9594761f378278880a2eeec8f9bde6f79d2f072a84e159ed4f6d216d45
File Type:

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