SONOGRAPHIC EVIDENCE OF ABNORMAL TRACHEAL CARTILAGE RING STRUCTURE IN CYSTIC FIBROSIS

Details

• Alternative Title:
  Laryngoscope
• Personal Author:
  Diwakar, Amit ; Adam, Ryan J. ; Michalski, Andrew S. ; Tamegnon, Monelle M. ; Fischer, Anthony J. ; Launspach, Jan L. ; Horan, Rebecca A. ; Kao, Simon C. ; Chaloner, Kathryn ; Meyerholz, David K. ; Stoltz, David A.
• Description:
  Objective
  
  Tracheal cartilage ring structural abnormalities have been reported in cystic fibrosis (CF) mice and pigs. Whether similar findings are present in humans with CF is unknown.
  
  Study Design
  
  Tracheal cartilage ring size and shape were measured in adults with (n=21) and without CF (n=18).
  
  Methods
  
  Ultrasonography was used in human subjects to non-invasively assess tracheal cartilage ring structure in both the sagittal and the transverse planes. Tracheal cartilage ring thickness was also determined from histological sections obtained from newborn non-CF and CF pigs. These values were compared with human data.
  
  Results
  
  Human CF tracheas had a greater width and were less circular in shape compared to non-CF subjects. CF tracheal cartilage rings had a greater midline cross sectional area and were thicker compared to non-CF rings. Maximal tracheal cartilage ring thickness was also greater in both newborn CF pigs and human adults with CF, compared to non-CF controls.
  
  Conclusion
  
  Our findings demonstrate that structural differences exist in tracheal cartilage rings in adults with CF. Comparison with newborn CF pig data suggests that some of these changes may be congenital in nature.
  
  
• Subjects:
  Adolescent Adult Airway Animals Article Cartilage Cystic Fibrosis Female Human Humans Male Swine Trachea Ultrasound Young Adult

  More +
• Source:
  Laryngoscope. 125(10):2398-2404.
• Pubmed ID:
  25827636
• Pubmed Central ID:
  PMC4578972
• Document Type:
  Journal Article
• Funding:
  DP2 HL117744/DP/NCCDPHP CDC HHS/United States ; DP2 HL117744/HL/NHLBI NIH HHS/United States ; HL051670/HL/NHLBI NIH HHS/United States ; HL091842/HL/NHLBI NIH HHS/United States ; P01 HL051670/HL/NHLBI NIH HHS/United States ; P01 HL091842/HL/NHLBI NIH HHS/United States ; P30 DK054759/DK/NIDDK NIH HHS/United States ; P30 ES005605/ES/NIEHS NIH HHS/United States
• Volume:
  125
• Issue:
  10
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:3fce2a0700257784c5faab87e22f13db37955f10953352c5ba33056189f0e70f
• Download URL:
  https://stacks.cdc.gov/view/cdc/36566/cdc_36566_DS1.pdf
• File Type:
  [PDF - 1.45 MB ]