Details:

Alternative Title:
Vaccine
Publisher's site:
http://dx.doi.org/10.1016/j.vaccine.2013.02.048
Personal Author:
Raczniak, Gregory A. ; Thomas, Timothy K. ; Bulkow, Lisa R. ; Negus, Susan E. ; Zanis, Carolyn L. ; ... More +
Raczniak, Gregory A. ; Thomas, Timothy K. ; Bulkow, Lisa R. ; Negus, Susan E. ; Zanis, Carolyn L. ; Bruce, Michael G. ; Spradling, Philip R. ; Teshale, Eyasu H. ; McMahon, Brian J. Less -
Description:
Background

Hepatitis A is mostly a self-limiting disease but causes substantial economic burden. Consequently, United States Advisory Committee for Immunization Practices recommends inactivated hepatitis A vaccination for all children beginning at age 1 year and for high risk adults. The hepatitis A vaccine is highly effective but the duration of protection is unknown.

Methods

We examined the proportion of children with protective hepatitis A antibody levels (anti-HAV ≥20 mIU/mL) as well as the geometric mean concentration (GMC) of anti-HAV in a cross sectional convenience sample of individuals aged 12–24 years, who had been vaccinated with a two-dose schedule in childhood, with the initial dose at least 5 years ago. We compared a subset of data from persons vaccinated with two-doses (720 EL.U.) at age 3–6 years with a demographically similar prospective cohort that received a three-dose (360 EL.U.) schedule and have been followed for 17 years.

Results

No significant differences were observed when comparing GMC between the two cohorts at 10 (P = 0.467), 12 (P = 0.496), and 14 (P = 0.175) years post-immunization. For the three-dose cohort, protective antibody levels remain for 17 years and have leveled-off over the past 7 years.

Conclusion

The two- and three-dose schedules provide similar protection >14 years after vaccination, indicating a booster dose is not needed at this time. Plateauing anti-HAV GMC levels suggest protective antibody levels may persist long-term.


Subject:
[+]
Adolescent
Article
Child
Child, Preschool
Cohort Studies
Female
Follow-Up Studies
Hepatitis A
Hepatitis A Antibodies
Hepatitis A Vaccines
Humans
Immunization Schedule
Male
Prospective Studies
Time Factors
Vaccination
Vaccines, Inactivated
Young Adult

Source:
Vaccine. 31(17):2152-2155.
Pubmed ID:
23470239
Pubmed Central ID:
PMC4648811
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States ; U01PS001097/PS/NCHHSTP CDC HHS/United States ; U50/CCU022279/PHS HHS/United States
CC999999/Intramural CDC HHS/United States ; U01PS001097/PS/NCHHSTP CDC HHS/United States ; U50/CCU022279/PHS HHS/United States Less -
Place as Subject:
United States
Collection(s):
Arctic Investigations Program
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:97400df5982a006923395ee5c2646148b5a9cc8ca3869843a664685237a9f864
File Type:

Supporting Files

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