Characteristics and Risk Factors of Cancer Associated Venous Thromboembolism☆

Details

• Alternative Title:
  Thromb Res
• Personal Author:
  Faiz, Ambarina S. ; Khan, Imran ; Beckman, Michele G. ; Bockenstedt, Paula ; Heit, John A. ; Kulkarni, Roshni ; Manco-Johnson, Marilyn ; Moll, Stephan ; Ortel, Thomas L. ; Philipp, Claire S.
• Description:
  Introduction
  
  The objective of this study was to examine the differences in commonly associated characteristics and risk factors of venous thromboembolism (VTE) between patients with and without cancer in a VTE population.
  
  Materials and Methods
  
  Uniform data were collected for patients with a diagnosis of VTE obtaining care at CDC funded Thrombosis Network Centers. Patient characteristics and risk factors were compared in VTE patients with and without cancer. Logistic regression was used to calculate the unadjusted and adjusted odds ratios (ORs) and 95% confidence intervals (CIs) to assess patient characteristics and thrombotic risk factors more frequently identified among VTE patients with cancer compared to those without cancer.
  
  Results
  
  Between August 2003 and April 2011, 3,115 adult patients with a diagnosis of VTE including 189 (6.1%) patients with active cancer participated in the multi-site thrombosis registry. VTE patients with cancer had a higher prevalence of PE and DVT in unusual sites compared to those without cancer. Thrombophilia was more common among VTE patients without cancer than those with cancer (25.1% vs 10.6%, p < 0.001). In adjusted analysis, age group ≥ 45 years (OR =5.20, 95% CI, 3.30, 8.18), surgery (OR =1.86, 95% CI, 1.19, 2.91), and hypertension (OR =1.66, 95% CI, 1.15, 2.40) were the VTE risk factors more commonly found among VTE patients with cancer.
  
  Conclusion
  
  The study identified several thrombotic risk factors more likely to be found with cancer associated VTE, which may help to characterize at risk cancer patients and to develop prevention and management strategies in this population.
  
  
• Keywords:
  Aged Aged, 80 And Over Age Distribution Cancer Causality Comorbidity Deep Vein Thrombosis Female Humans Hypertension Incidence Male Malignancy Middle Aged Neoplasms Pulmonary Embolism Registries Risk Factors Sex Distribution Smoking Thrombophilia United States Venous Thromboembolism

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• Source:
  Thromb Res. 136(3):535-541
• Pubmed ID:
  26168693
• Pubmed Central ID:
  PMC4643665
• Document Type:
  Journal Article
• Funding:
  U01 DD000235/DD/NCBDD CDC HHSUnited States/ ; DD000016/DD/NCBDD CDC HHSUnited States/ ; U01 DD000014/DD/NCBDD CDC HHSUnited States/ ; DD000014/DD/NCBDD CDC HHSUnited States/ ; DD000235/DD/NCBDD CDC HHSUnited States/ ; DD000017/DD/NCBDD CDC HHSUnited States/ ; U18 DD000014/DD/NCBDD CDC HHSUnited States/ ; U01 DD000292/DD/NCBDD CDC HHSUnited States/ ; DD000292/DD/NCBDD CDC HHSUnited States/ ; U01 DD000016/DD/NCBDD CDC HHSUnited States/ ; DD000015/DD/NCBDD CDC HHSUnited States/ ; U18 DD000017/DD/NCBDD CDC HHSUnited States/ ; U18 DD000016/DD/NCBDD CDC HHSUnited States/ ; U18 DD000015/DD/NCBDD CDC HHSUnited States/ ; U01 DD000017/DD/NCBDD CDC HHSUnited States/
• Volume:
  136
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:2bfa58cc6b4b3910ff89d2ca55da162b59fb4a2df87bcbfe5761704c1e6a295f
• Download URL:
  https://stacks.cdc.gov/view/cdc/36477/cdc_36477_DS1.pdf
• File Type:
  [PDF - 559.42 KB ]