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Characteristics and Risk Factors of Cancer Associated Venous Thromboembolism☆
  • Published Date:
    Jul 05 2015
  • Source:
    Thromb Res. 136(3):535-541.
Filetype[PDF-559.42 KB]


Details:
  • Pubmed ID:
    26168693
  • Pubmed Central ID:
    PMC4643665
  • Description:
    Introduction

    The objective of this study was to examine the differences in commonly associated characteristics and risk factors of venous thromboembolism (VTE) between patients with and without cancer in a VTE population.

    Materials and Methods

    Uniform data were collected for patients with a diagnosis of VTE obtaining care at CDC funded Thrombosis Network Centers. Patient characteristics and risk factors were compared in VTE patients with and without cancer. Logistic regression was used to calculate the unadjusted and adjusted odds ratios (ORs) and 95% confidence intervals (CIs) to assess patient characteristics and thrombotic risk factors more frequently identified among VTE patients with cancer compared to those without cancer.

    Results

    Between August 2003 and April 2011, 3,115 adult patients with a diagnosis of VTE including 189 (6.1%) patients with active cancer participated in the multi-site thrombosis registry. VTE patients with cancer had a higher prevalence of PE and DVT in unusual sites compared to those without cancer. Thrombophilia was more common among VTE patients without cancer than those with cancer (25.1% vs 10.6%, p < 0.001). In adjusted analysis, age group ≥ 45 years (OR =5.20, 95% CI, 3.30, 8.18), surgery (OR =1.86, 95% CI, 1.19, 2.91), and hypertension (OR =1.66, 95% CI, 1.15, 2.40) were the VTE risk factors more commonly found among VTE patients with cancer.

    Conclusion

    The study identified several thrombotic risk factors more likely to be found with cancer associated VTE, which may help to characterize at risk cancer patients and to develop prevention and management strategies in this population.

  • Document Type:
  • Collection(s):
  • Funding:
    U01 DD000235/DD/NCBDD CDC HHS/United States
    DD000016/DD/NCBDD CDC HHS/United States
    U01 DD000014/DD/NCBDD CDC HHS/United States
    DD000014/DD/NCBDD CDC HHS/United States
    DD000235/DD/NCBDD CDC HHS/United States
    U18 DD000015/DD/NCBDD CDC HHS/United States
    U01 DD000017/DD/NCBDD CDC HHS/United States
    DD000017/DD/NCBDD CDC HHS/United States
    U18 DD000014/DD/NCBDD CDC HHS/United States
    U01 DD000292/DD/NCBDD CDC HHS/United States
    DD000292/DD/NCBDD CDC HHS/United States
    U01 DD000016/DD/NCBDD CDC HHS/United States
    DD000015/DD/NCBDD CDC HHS/United States
    U18 DD000016/DD/NCBDD CDC HHS/United States
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