Details:

Alternative Title:
J Matern Fetal Neonatal Med
Publisher's site:
http://dx.doi.org/10.3109/14767058.2011.569614
Personal Author:
Jones, Nicole M. ; Holzman, Claudia ; Tian, Yan ; Witkin, Steven S. ; Genc, Mehmet ; ... More +
Jones, Nicole M. ; Holzman, Claudia ; Tian, Yan ; Witkin, Steven S. ; Genc, Mehmet ; Friderici, Karen ; Fisher, Rachel ; Sezen, Devrim ; Babula, Oksana ; Jernigan, Katherine A. ; Chung, Hwan ; Wirth, Julia ; Less -
Description:
Objective There is little information about the combination of genetic variability in pregnant women and their children in relation to the risk of preterm delivery (PTD). In a sub-cohort of 487 non-Hispanic white and 288 African-American mother/child pairs, the Pregnancy Outcomes and Community Health Study assessed ten functional polymorphisms in nine genes involved in innate immune function. Methods Race-stratified weighted logistic regression models were used to calculate odds ratios for genotype and PTD/PTD subtypes. Polymorphisms significantly associated with PTD/PTD subtypes were tested for mother/child genotype interactions. Results Three maternal polymorphisms (IL-1 receptor antagonist intron two repeat (IL-1RN), matrix metalloproteinase-9 -C1562T, and TNF receptor two T198G (TNFR2)) and three child polymorphisms (IL1-RN, tumor necrosis factor-alpha -G308A, and TNFR2) were associated with PTD, but associations varied by PTD subtype and race. Two interactions were detected for maternal and child genotype. Among non-Hispanic white women, the odds of PTD was higher when both mother and child carried the IL-1RN allele two (additive interaction p<.05). Among African-American women, the odds of PTD was higher when both mother and child carried the TNFR2 G allele (multiplicative interaction p<.05). Conclusion These results highlight the importance of assessing both maternal and child genotype in relation to PTD risk.
Subject:
[+]
Adult
African Americans
Female
Follow-Up Studies
Humans
Immunity, Innate
Infant, Newborn
Infant, Premature
Logistic Models
Male
Obstetric Labor, Premature
Polymorphism, Genetic
Pregnancy
Premature Birth
Questionnaires
Risk
Risk Factors
Whites
Young Adult

Source:
J Matern Fetal Neonatal Med. 25(3):240-247. ;
Pubmed ID:
21627550
Pubmed Central ID:
PMC4643033
Document Type:
Journal Article ;
Funding:
R01 HD 34543-01/HD/NICHD NIH HHS/United States ; R01 HD034543/HD/NICHD NIH HHS/United States ; R01 HD034543-07/HD/NICHD NIH HHS/United States ; R01 HD34543/HD/NICHD NIH HHS/United States ; T32 HD046377/HD/NICHD NIH HHS/United States ; ... More +
R01 HD 34543-01/HD/NICHD NIH HHS/United States ; R01 HD034543/HD/NICHD NIH HHS/United States ; R01 HD034543-07/HD/NICHD NIH HHS/United States ; R01 HD34543/HD/NICHD NIH HHS/United States ; T32 HD046377/HD/NICHD NIH HHS/United States ; U01 DP00143-01/DP/NCCDPHP CDC HHS/United States ; Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:3151f307f1b9602850640961f5fe8dd439e3170b266cdc51d215314a791d39c2
File Type:

Supporting Files

• nihms434484.nxml

  bin

More +