J Matern Fetal Neonatal Med

Objective

There is little information about the combination of genetic variability in pregnant women and their children in relation to the risk of preterm delivery (PTD). In a sub-cohort of 487 non-Hispanic white and 288 African-American mother/child pairs, the Pregnancy Outcomes and Community Health Study assessed ten functional polymorphisms in nine genes involved in innate immune function.

Methods

Race-stratified weighted logistic regression models were used to calculate odds ratios for genotype and PTD/PTD subtypes. Polymorphisms significantly associated with PTD/PTD subtypes were tested for mother/child genotype interactions.

Results

Three maternal polymorphisms (IL-1 receptor antagonist intron two repeat (IL-1RN), matrix metalloproteinase-9 -C1562T, and TNF receptor two T198G (TNFR2)) and three child polymorphisms (IL1-RN, tumor necrosis factor-alpha -G308A, and TNFR2) were associated with PTD, but associations varied by PTD subtype and race. Two interactions were detected for maternal and child genotype. Among non-Hispanic white women, the odds of PTD was higher when both mother and child carried the IL-1RN allele two (additive interaction p<.05). Among African-American women, the odds of PTD was higher when both mother and child carried the TNFR2 G allele (multiplicative interaction p<.05).

Conclusion

These results highlight the importance of assessing both maternal and child genotype in relation to PTD risk.

21627550

PMC4643033

Journal Article

CDC Public Access