21627550

PMC4643033

Objective

There is little information about the combination of genetic variability in pregnant women and their children in relation to the risk of preterm delivery (PTD). In a sub-cohort of 487 non-Hispanic white and 288 African-American mother/child pairs, the Pregnancy Outcomes and Community Health Study assessed ten functional polymorphisms in nine genes involved in innate immune function.

Methods

Race-stratified weighted logistic regression models were used to calculate odds ratios for genotype and PTD/PTD subtypes. Polymorphisms significantly associated with PTD/PTD subtypes were tested for mother/child genotype interactions.

Results

Three maternal polymorphisms (IL-1 receptor antagonist intron two repeat (IL-1RN), matrix metalloproteinase-9 -C1562T, and TNF receptor two T198G (TNFR2)) and three child polymorphisms (IL1-RN, tumor necrosis factor-alpha -G308A, and TNFR2) were associated with PTD, but associations varied by PTD subtype and race. Two interactions were detected for maternal and child genotype. Among non-Hispanic white women, the odds of PTD was higher when both mother and child carried the IL-1RN allele two (additive interaction p<.05). Among African-American women, the odds of PTD was higher when both mother and child carried the TNFR2 G allele (multiplicative interaction p<.05).

Conclusion

These results highlight the importance of assessing both maternal and child genotype in relation to PTD risk.

CDC Public Access

R01 HD 34543-01/HD/NICHD NIH HHS/United States
R01 HD034543/HD/NICHD NIH HHS/United States
R01 HD034543-07/HD/NICHD NIH HHS/United States
R01 HD34543/HD/NICHD NIH HHS/United States
T32 HD046377/HD/NICHD NIH HHS/United States
T32 HD046377/HD/NICHD NIH HHS/United States
U01 DP00143-01/DP/NCCDPHP CDC HHS/United States