Innate immune system gene polymorphisms in maternal and child genotype and risk of preterm delivery

Jones, Nicole M.; Holzman, Claudia; Tian, Yan; Witkin, Steven S.; Genc, Mehmet; Friderici, Karen; Fisher, Rachel; Sezen, Devrim; Babula, Oksana; Jernigan, Katherine A.; Chung, Hwan; Wirth, Julia

doi:10.3109/14767058.2011.569614

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Innate immune system gene polymorphisms in maternal and child genotype and risk of preterm delivery

Published Date:

Jun 01 2011

Publisher's site:

http://dx.doi.org/10.3109/14767058.2011.569614 New Site Icon

Source:

J Matern Fetal Neonatal Med. 25(3):240-247.

[PDF-283.79 KB]

Details:

Personal Authors:

Jones, Nicole M. ; Holzman, Claudia ; Tian, Yan ; Witkin, Steven S. ; Genc, Mehmet ; ... More ▼

Keywords:

[+]

Pubmed ID:

21627550

Pubmed Central ID:

PMC4643033

Description:

Objective

There is little information about the combination of genetic variability in pregnant women and their children in relation to the risk of preterm delivery (PTD). In a sub-cohort of 487 non-Hispanic white and 288 African-American mother/child pairs, the Pregnancy Outcomes and Community Health Study assessed ten functional polymorphisms in nine genes involved in innate immune function.

Methods

Race-stratified weighted logistic regression models were used to calculate odds ratios for genotype and PTD/PTD subtypes. Polymorphisms significantly associated with PTD/PTD subtypes were tested for mother/child genotype interactions.

Results

Three maternal polymorphisms (IL-1 receptor antagonist intron two repeat (IL-1RN), matrix metalloproteinase-9 -C1562T, and TNF receptor two T198G (TNFR2)) and three child polymorphisms (IL1-RN, tumor necrosis factor-alpha -G308A, and TNFR2) were associated with PTD, but associations varied by PTD subtype and race. Two interactions were detected for maternal and child genotype. Among non-Hispanic white women, the odds of PTD was higher when both mother and child carried the IL-1RN allele two (additive interaction p<.05). Among African-American women, the odds of PTD was higher when both mother and child carried the TNFR2 G allele (multiplicative interaction p<.05).

Conclusion

These results highlight the importance of assessing both maternal and child genotype in relation to PTD risk.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

R01 HD 34543-01/HD/NICHD NIH HHS/United States
R01 HD034543/HD/NICHD NIH HHS/United States
R01 HD034543-07/HD/NICHD NIH HHS/United States
R01 HD34543/HD/NICHD NIH HHS/United States
T32 HD046377/HD/NICHD NIH HHS/United States
T32 HD046377/HD/NICHD NIH HHS/United States
U01 DP00143-01/DP/NCCDPHP CDC HHS/United States

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