Genetic diversity and C2-like subgenogroup strains of enterovirus 71, Taiwan, 2008

Details

• Alternative Title:
  Virol J
• Personal Author:
  Huang, Yuan-Pin ; Lin, Tsuey-Li ; Hsu, Li-Ching ; Chen, Yu-Ju ; Tseng, Yin-Hsin ; Hsu, Chiu-Chu ; Fan, Wen-Bin ; Yang, Jyh-Yuan ; Chang, Feng-Yee ; Wu, Ho-Sheng
• Description:
  Background
  
  Human enterovirus 71 (EV-71) is known of having caused numerous outbreaks of hand-foot-mouth disease, and other clinical manifestations globally. In 2008, 989 EV-71 strains were isolated in Taiwan.
  
  Results
  
  In this study, the genetic and antigenic properties of these strains were analyzed and the genetic diversity of EV-71 subgenogroups surfacing in Taiwan was depicted, which includes 3 previously reported subgenogroups of C5, B5, and C4, and one C2-like subgenogroup. Based on the phylogenetic analyses using their complete genome nucleotide sequences and neutralization tests, the C2-like subgenogroup forms a genetically distinct cluster from other subgenogroups, and the antisera show a maximum of 128-fold decrease of neutralization titer against this subgenogroup. In addition, the subgenogroup C4 isolates of 2008 were found quite similar genetically to the Chinese strains that caused outbreaks in recent years and thus they should be carefully watched.
  
  Conclusions
  
  Other than to be the first report describing the existence of C2-like subgenogroup of EV-71 in Taiwan, this article also foresees a potential of subgenogroup C4 outbreaks in Taiwan in the near future.
  
  
• Subjects:
  Adolescent Adult Antibodies, Neutralizing Antibodies, Viral Child Child, Preschool Cluster Analysis Enterovirus A, Human Enterovirus Infections Female Genetic Variation Genome, Viral Humans Infant Infant, Newborn Male Molecular Sequence Data Neutralization Tests Phylogeny Research RNA, Viral Sequence Analysis, DNA Taiwan Young Adult

  More +
• Source:
  Virol J. 2010; 7:277.
• Document Type:
  Journal Article
• Volume:
  7
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:5ef288029a58a4bda8782343f43a10fa64be64278b734ed7a45f9c02416a674a
• Download URL:
  https://stacks.cdc.gov/view/cdc/3636/cdc_3636_DS1.pdf
• File Type:
  [PDF - 2.72 MB ]