Details:

Alternative Title:
Virol J
Personal Author:
Huang, Yuan-Pin ; Lin, Tsuey-Li ; Hsu, Li-Ching ; Chen, Yu-Ju ; Tseng, Yin-Hsin ; ... More +
Huang, Yuan-Pin ; Lin, Tsuey-Li ; Hsu, Li-Ching ; Chen, Yu-Ju ; Tseng, Yin-Hsin ; Hsu, Chiu-Chu ; Fan, Wen-Bin ; Yang, Jyh-Yuan ; Chang, Feng-Yee ; Wu, Ho-Sheng Less -
Description:
Background

Human enterovirus 71 (EV-71) is known of having caused numerous outbreaks of hand-foot-mouth disease, and other clinical manifestations globally. In 2008, 989 EV-71 strains were isolated in Taiwan.

Results

In this study, the genetic and antigenic properties of these strains were analyzed and the genetic diversity of EV-71 subgenogroups surfacing in Taiwan was depicted, which includes 3 previously reported subgenogroups of C5, B5, and C4, and one C2-like subgenogroup. Based on the phylogenetic analyses using their complete genome nucleotide sequences and neutralization tests, the C2-like subgenogroup forms a genetically distinct cluster from other subgenogroups, and the antisera show a maximum of 128-fold decrease of neutralization titer against this subgenogroup. In addition, the subgenogroup C4 isolates of 2008 were found quite similar genetically to the Chinese strains that caused outbreaks in recent years and thus they should be carefully watched.

Conclusions

Other than to be the first report describing the existence of C2-like subgenogroup of EV-71 in Taiwan, this article also foresees a potential of subgenogroup C4 outbreaks in Taiwan in the near future.


Subject:
[+]
Adolescent
Adult
Antibodies, Neutralizing
Antibodies, Viral
Child
Child, Preschool
Cluster Analysis
Enterovirus A, Human
Enterovirus Infections
Female
Genetic Variation
Genome, Viral
Humans
Infant
Infant, Newborn
Male
Molecular Sequence Data
Neutralization Tests
Phylogeny
Research
RNA, Viral
Sequence Analysis, DNA
Taiwan
Young Adult

Source:
Virol J. 2010; 7:277.
Document Type:
Journal Article
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:5ef288029a58a4bda8782343f43a10fa64be64278b734ed7a45f9c02416a674a
File Type:

Supporting Files

• 	1743-422X-7-277-S1.DOC	doc
  	1743-422X-7-277.nxml	txt
  	license.txt	txt
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