Details:

Alternative Title:
Euro Surveill
Personal Author:
Turner, Nikki ; Pierse, Nevil ; Bissielo, Ange ; Huang, Q Sue ; Radke, Sarah ; ... More +
Turner, Nikki ; Pierse, Nevil ; Bissielo, Ange ; Huang, Q Sue ; Radke, Sarah ; Baker, Michael ; Widdowson, Marc-Alain ; Kelly, Heath Less -
Description:
This study reports the first vaccine effectiveness (VE) estimates for the prevention of general practice visits and hospitalisations for laboratory-confirmed influenza from an urban population in Auckland, New Zealand, in the same influenza season (2013). A case test-negative design was used to estimate propensity-adjusted VE in both hospital and community settings. Patients with a severe acute respiratory infection (SARI) or influenza-like illness (ILI) were defined as requiring hospitalisation (SARI) or attending a general practice (ILI) with a history of fever or measured temperature ≥38 °C, cough and onset within the past 10 days. Those who tested positive for influenza virus were cases while those who tested negative were controls. Results were analysed to 7 days post symptom onset and adjusted for the propensity to be vaccinated and the timing during the influenza season. Influenza vaccination provided 52% (95% CI: 32 to 66) protection against laboratory-confirmed influenza hospitalisation and 56% (95% CI: 34 to 70) against presenting to general practice with influenza. VE estimates were similar for all types and subtypes. This study found moderate effectiveness of influenza vaccine against medically attended and hospitalised influenza in New Zealand, a temperate, southern hemisphere country during the 2013 winter season.
Subject:
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Adult
Article
Case-Control Studies
Female
Hospitalization
Humans
Infant
Infant, Newborn
Influenza, Human
Influenza A Virus, H1N1 Subtype
Influenza Vaccines
Logistic Models
Male
Middle Aged
Multivariate Analysis
Primary Health Care
Reverse Transcriptase Polymerase Chain Reaction
Seasons
Sentinel Surveillance
Urban Population
Young Adult

Source:
Euro Surveill. 19(34).
Pubmed ID:
25188614
Pubmed Central ID:
PMC4627593
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Place as Subject:
New Zealand
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:e6808a6847028284a9eac8393146f978c8908955515463c7357ed0c7593fa617
File Type:

Supporting Files

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