Details:

Alternative Title:
Clin Neuropathol
Publisher's site:
http://dx.doi.org/10.5414/NP300843
Personal Author:
Reis, Gerald F. ; Ritter, Jana M. ; Bellini, William J. ; Rota, Paul A. ; Bollen., Andrew
Reis, Gerald F. ; Ritter, Jana M. ; Bellini, William J. ; Rota, Paul A. ; Bollen., Andrew Less -
Description:
A 29-year-old pregnant woman developed progressively worsening encephalopathy, left hemiparesis, and hemodynamic instability over a 6-week period. Initial brain MRI and work-up for infectious and autoimmune causes were normal, although elevated IgG and oligoclonal bands were seen on analysis of the cerebrospinal fluid (CSF). After uncomplicated spontaneous delivery of a preterm healthy infant, her condition worsened. Repeat brain MRI demonstrated generalized volume loss and evidence of corticospinal tract degeneration. She underwent a brain biopsy, which showed characteristic viral inclusions of the type seen in subacute sclerosing panencephalitis (SSPE). The diagnosis was confirmed by immunohistochemistry and electron microscopy, and additional CSF analysis also showed markedly elevated IgG titer for measles. Sequence analysis of the nucleoprotein gene N-450 demonstrated a close relationship to the sequences of viruses in genotype D7. This case documents an ~ 6-month progression to death of SSPE in a pregnant woman.
Subject:
[+]
Adult
Article
Brain
Fatal Outcome
Female
Hemodynamics
Humans
Magnetic Resonance Imaging
Pregnancy
Pregnancy Complications
Subacute Sclerosing Panencephalitis

Source:
Clin Neuropathol. 34(5):258-266.
Pubmed ID:
25943270
Pubmed Central ID:
PMC4627486
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:a4be5b98eb4b9abf9687db64abb3792534cea6eeed6afd8764490b4d6d7dbf98
File Type:

Supporting Files

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