Details:

Alternative Title:
Clin Infect Dis
Personal Author:
Muehlenbachs, Atis ; Fata, Cynthia R. ; Lambert, Amy J. ; Paddock, Christopher D. ; Velez, Jason O. ; ... More +
Muehlenbachs, Atis ; Fata, Cynthia R. ; Lambert, Amy J. ; Paddock, Christopher D. ; Velez, Jason O. ; Blau, Dianna M. ; Staples, J. Erin ; Karlekar, Mohana B. ; Bhatnagar, Julu ; Nasci, Roger S. ; Zaki, Sherif R. Less -
Description:
Background

Heartland virus (HRTV) is a tick-borne phlebovirus recently described in Missouri that is associated with fever, leukopenia and thrombocytopenia. The virus has also been detected in Ambylommaamericanum ticks.

Methods and Results

Here we report the first fatal case of HRTV disease in an 80 year-old Tennessee resident. He was hospitalized with fever, confusion, leukopenia, and thrombocytopenia and developed multi-organ failure and hemorrhage. A tick-borne illness was suspected and testing for ehrlichiosis was negative. He died on hospital day 15 and autopsy specimens were tested for various pathogens as part of an unexplained death evaluation. HRTV antigens were detected in post-mortem spleen and lymph nodes by immunohistochemistry, and HRTV was detected in pre-mortem blood by RT-PCR and by isolation in cell culture.

Conclusions

This case demonstrates that HRTV infection can cause severe disease and death and expands the geographic range of HRTV within the United States.


Subject:
[+]
Aged, 80 And Over
Article
Fatal Outcome
Humans
Male
Phlebotomus Fever
Phlebovirus
Pulmonary Disease, Chronic Obstructive
Risk Factors
Serotyping
Tennessee

Source:
Clin Infect Dis. 59(6):845-850
Pubmed ID:
24917656
Pubmed Central ID:
PMC4608028
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:ee9e02a062c17e8a92b44a3f92543da17e83a3b0695e1115cb66a4496a0e4c66
File Type:

Supporting Files

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