Thottapalayam virus is genetically distant to the rodent-borne hantaviruses, consistent with its isolation from the Asian house shrew (Suncus murinus)

Yadav, Pragya D; Vincent, Martin J; Nichol, Stuart T

doi:10.1186/1743-422x-4-80

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Thottapalayam virus is genetically distant to the rodent-borne hantaviruses, consistent with its isolation from the Asian house shrew (Suncus murinus)

Supporting Files Public Domain

2007/09/21
By Yadav, Pragya D ; Vincent, Martin J ; Nichol, Stuart T
https://doi.org/10.1186/1743-422x-4-80

File Language:

English

Details

Journal Article:

Virol J
Personal Author:

Yadav, Pragya D ; Vincent, Martin J ; Nichol, Stuart T
Description:

Thottapalayam (TPM) virus belongs to the genus Hantavirus, family Bunyaviridae. The genomes of hantaviruses consist of three negative-stranded RNA segments (S, M and L) encoding the virus nucleocapsid (N), glycoprotein (Gn, Gc), and polymerase (L) proteins, respectively. The genus Hantavirus contains predominantly rodent-borne viruses, with the prominent exception of TPM virus which was isolated in India in 1964 from an insectivore, Suncus murinus, commonly referred to as the Asian house shrew or brown musk shrew. Analysis of the available TPM virus S (1530 nt) RNA genome segment sequence and the newly derived M (3621 nt) and L (6581 nt) segment sequences demonstrate that the entire TPM virus genome is very unique. Remarkably high sequence differences are seen at the nucleotide (up to S - 47%, M - 49%, L - 38%) and protein (up to N - 54%, Gn/Gc - 57% and L - 39%) levels relative to the rodent-borne hantaviruses, consistent with TPM virus having a unique host association.
Subjects:
Keywords:
- Hantavirus
- HPS
DOI:

https://doi.org/10.1186/1743-422x-4-80
Pubmed ID:

17711577
Pubmed Central ID:

PMC1997112
Document Type:

Text ; Journal Article
Genre:

Journal Article
Rights:

Open Access
CIO:

National Center for Zoonotic, Vector-borne, and Enteric Diseases (NCZVED)
Division:

DVRD - Division of Viral and Rickettsial Diseases
Topic:

Diseases & Conditions
Pages in Document:

5 pdf pages
Volume:

4
Issue:

80
Citation:

Virol J. 2007; 4:80.
Download URL:

https://stacks.cdc.gov/view/cdc/3624/cdc_3624_DS1.pdf
File Type:

[PDF - 279.21 KB]
Collection(s):

CDC Public Access
Main Document Checksum:

urn:sha-512:7ebf1c805d920d4e12cd89d54c0e67059cb5fc21886b44226078b64edf264ce7c22b40961bc1414aa451dd394f91d516e44da4bec613b4d74c8d5b3aeb40cf3f

File Language:

English

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