Details:

Alternative Title:
Virol J
Personal Author:
Yadav, Pragya D ; Vincent, Martin J ; Nichol, Stuart T
Yadav, Pragya D ; Vincent, Martin J ; Nichol, Stuart T Less -
Description:
Thottapalayam (TPM) virus belongs to the genus Hantavirus, family Bunyaviridae. The genomes of hantaviruses consist of three negative-stranded RNA segments (S, M and L) encoding the virus nucleocapsid (N), glycoprotein (Gn, Gc), and polymerase (L) proteins, respectively. The genus Hantavirus contains predominantly rodent-borne viruses, with the prominent exception of TPM virus which was isolated in India in 1964 from an insectivore, Suncus murinus, commonly referred to as the Asian house shrew or brown musk shrew. Analysis of the available TPM virus S (1530 nt) RNA genome segment sequence and the newly derived M (3621 nt) and L (6581 nt) segment sequences demonstrate that the entire TPM virus genome is very unique. Remarkably high sequence differences are seen at the nucleotide (up to S - 47%, M - 49%, L - 38%) and protein (up to N - 54%, Gn/Gc - 57% and L - 39%) levels relative to the rodent-borne hantaviruses, consistent with TPM virus having a unique host association.
Subject:
[+]
Animals
Genetic Variation
Hantavirus
Phylogeny
Rodentia
Short Report
Shrews

Source:
Virol J. 2007; 4:80.
Document Type:
Journal Article
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:3c9a764a3625495870f93845f6f448d321f1169c896b2936baa4c61d49ee8a1d
File Type:

Supporting Files

• 	1743-422X-4-80-1.gif	gif
  	1743-422X-4-80-1.jpg	jpeg
  	1743-422X-4-80.nxml	txt
  	license.txt	txt

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