Survival of Children With Hypoplastic Left Heart Syndrome

Details

• Alternative Title:
  Pediatrics
• Personal Author:
  Siffel, Csaba ; Riehle-Colarusso, Tiffany ; Oster, Matthew E. ; Correa, Adolfo
• Description:
  OBJECTIVE
  
  To examine the survival of infants with hypoplastic left heart syndrome (HLHS) and potential influence of demographic and clinical characteristics on survival using population-based data.
  
  METHODS
  
  Infants with nonsyndromic HLHS (n = 212) born between 1979 and 2005 were identified through the Metropolitan Atlanta Congenital Defects Program. Vital status was ascertained through 2009 based on linkage with vital records. We estimated Kaplan-Meier survival probabilities stratified by select demographic and clinical characteristics.
  
  RESULTS
  
  The overall survival probability to 2009 was 24% and significantly improved over time: from 0% in 1979–1984 to 42% in 1999–2005. Survival probability was 66% during the first week, 27% during the first year of life, and 24% during the first 10 years. Survival of very low and low birth weight or preterm infants and those born in high-poverty neighborhoods was significantly poorer. For children with information on surgical intervention (n = 88), the overall survival was 52%, and preterm infants had significantly poorer survival (31%) compared with term infants (56%). For children who survived to 1 year of age, long-term survival was ~90%.
  
  CONCLUSIONS
  
  Survival to adolescence of children with nonsyndromic HLHS born in metropolitan Atlanta has significantly improved in recent years, with those born full term, with normal birth weight, or in a low-poverty neighborhood having a higher survival probability. Survival beyond infancy to adolescence is high. A better understanding of the growing population of survivors with HLHS is needed to inform resource planning.
  
  
• Subjects:
  Child Female Follow-Up Studies Humans Hypoplastic Left Heart Syndrome Infant Infant, Newborn Infant, Premature Male Probability Prognosis Risk Factors Survival Analysis

  More +
• Source:
  Pediatrics. 136(4):e864-e870
• Pubmed ID:
  26391936
• Pubmed Central ID:
  PMC4663985
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States
• Place as Subject:
  Georgia
• Volume:
  136
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:eb5324e9c2b9b383b88fb60ba44408ad085b35b7232a68db763b42aed9c86e11
• Download URL:
  https://stacks.cdc.gov/view/cdc/36239/cdc_36239_DS1.pdf
• File Type:
  [PDF - 220.63 KB ]