Details:

Alternative Title:
J Int Assoc Provid AIDS Care
Publisher's site:
http://dx.doi.org/10.1177/2325957415600799
Personal Author:
Young, Benjamin ; Hart, Rachel L. D. ; Buchacz, Kate ; Scott, Mia ; Palella, Frank ; ... More +
Young, Benjamin ; Hart, Rachel L. D. ; Buchacz, Kate ; Scott, Mia ; Palella, Frank ; Brooks, John T. Less -
Corporate Authors:
for the HIV Outpatient Study (HOPS)
Description:
The authors sought to assess whether viral load (VL) monitoring frequency was associated with differential rates of virologic failure (VF) among HIV Outpatient Study (HOPS) participants seen during 1999 to 2013, who had maintained VL <50 copies/mL, CD4 counts ≥300 cells/mm(3), and been prescribed a stable combination antiretroviral regimen for at least 2 years. The authors required VL and CD4 testing to have occurred regularly for the entire 2-year period. The authors assessed rates of VF comparing patients who maintained a frequent VL testing (≥3 VLs) to those who shifted to a less frequent schedule (2 VL) after the 2-year period. Virologic failure was observed among 116 of 573 participants. The authors did not detect statistically significant difference in frequency of VF among patients undergoing frequent (21.0%) versus less frequent VL testing (19.6%), even after multivariable adjustment. Biannual VL monitoring for stable patients with aviremia could generate substantial cost savings without the increased risk of VF.
Subject:
[+]
Adolescent
Adult
Anti-HIV Agents
Antiretroviral Therapy, Highly Active
Article
CD4 Lymphocyte Count
Cohort Studies
Diagnostics
Drug Resistance, Viral
Drug Therapy, Combination
Female
Follow-Up Studies
HIV
HIV Infections
Humans
Male
Middle Aged
Outpatients
Treatment Failure
Viral Load
Young Adult
Viral Load

Source:
J Int Assoc Provid AIDS Care. 14(6):536-543.
Pubmed ID:
26293905
Pubmed Central ID:
PMC4657746
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:b73ece678bfa1920744562f4ae4e7db0416fe735ff4b2e6e6e08355f5b31230b
File Type:

Supporting Files

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