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NIOSH skin notation (SK) profile : Dieldrin [CAS No. 60-57-1]
  • Published Date:
    July 2015
  • Language:
    English
Filetype[PDF - 369.97 KB]


Details:
  • Corporate Authors:
    National Institute for Occupational Safety and Health.
  • Description:
    As the largest organ of the body, the skin performs multiple critical functions, such as serving as the primary barrier to the external environment. For this reason, the skin is often exposed to potentially hazardous agents, including chemicals, which may contribute to the onset of a spectrum of adverse health effects ranging from localized damage (e.g., irritant contact dermatitis and corrosion) to induction of immune-mediated responses (e.g., allergic contact dermatitis and pulmonary responses), or systemic toxicity (e.g., neurotoxicity and hepatoxicity). Understanding the hazards related to skin contact with chemicals is a critical component of modern occupational safety and health programs.

    This skin notation profile presents (1) a brief summary of epidemiological and toxicological data associated with skin contact with dieldrin and (2) the rationale behind the hazardspecific skin notation (SK) assignment for dieldrin. The SK assignment is based on the scientific rationale and logic outlined in the Current Intelligence Bulletin (CIB) 61: A Strategy for Assigning New NIOSH Skin Notations [NIOSH 2009]. The summarized information and health hazard assessment are limited to an evaluation of the potential health effects of dermal exposure to dieldrin. A literature search was conducted through August 2014 to identify information on dieldrin, including but not limited to data relating to its toxicokinetics, acute toxicity, repeated-dose systemic toxicity, carcinogenicity, biological system/function-specific effects (including reproductive and developmental effects and immunotoxicity), irritation, and sensitization. Information was considered from studies of humans, animals, or appropriate modeling systems that are relevant to assessing the effects of dermal exposure to dieldrin.

    Suggested citation: NIOSH [2015]. NIOSH skin notation profile: Dieldrin. By Hudson NL, Dotson GS. Cincinnati, OH: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 2015-194

    NIOSHTIC No 20046776

    f15_snp_dieldrin_2015-194.pdf

  • Document Type:
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