NIOSH Skin Notation (SK) Profile: Phosdrin [CAS No. 7786-34-7]

Details

• Alternative Title:
  NIOSH skin notation profile
• Journal Article:
  National Institute for Occupational Safety and Health
• Personal Author:
  Hudson, Naomi L. ; Dotson, G. Scott
• Description:
  Toxicokinetic data available on rabbits [Schellenberger et al. 1965] and results of a mathematical model indicate that phosdrin has the potential to be absorbed through the skin and become systemically available. Acute toxicity data on rats and mice [Kodama et al. 1954; Edson 1960; Gaines 1960; Skinner and Kilgore 1982a] and several occupational exposure datasets [California DPH 1958; NIOSH 1984; Midtling et al. 1985; Coye et al. 1986, 1987; Jauhialnen et al. 1992] provide sufficient evidence that phosdrin has the potential to be acutely toxic; may cause systemic toxicity, including ChE inhibition; and is potentially fatal following dermal exposure. No studies were identified that investigated the potential of the substance to cause skin irritation under occupational exposure or in standard skin irritation tests in animals. There were no diagnostic (human patch) tests or predictive tests in animals that evaluated the skin sensitization potential of phosdrin. Therefore, on the basis of these assessments, phosdrin is assigned a composite skin notation of SK: SYS (FATAL). Table 3 summarizes the skin hazard designations for phosdrin previously issued by NIOSH and other organizations. The equivalent dermal designation for phosdrin, according to the Globally Harmonized System (GHS) for the Classification and Labelling of Chemicals, is Acute Toxicity Category 1 (Hazard statement: Fatal in contact with the skin) [European Parliament 2008]. [Description provided by NIOSH]
• Subjects:
  Animals Chlorine Compounds Epidemiology Hazardous Substances Insecticides Laboratories Nervous System Nervous System Disorders Occupational Health Risk Assessment Risk Factors Safety Skin Toxicology

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• Keywords:
  Skin-exposure; Skin; Exposure-levels; Risk-factors; Epidemiology; Toxicology; Acute-toxicity; Laboratory-animals; Animal-studies; Animals; Kinetics; Chemical-kinetics; Biological-systems; Dose-response; Lethal-dose; Organo-chlorine-compounds; Pesticides; Central-nervous-system; Central-nervous-system-disorders; Dermal-exposure
• Source:
  Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 2015-226, 2015 Sep; :1-8
• Series:
  NIOSH Numbered Publications
• Subseries:
  Skin Notation Profile
• DOI:
  https://doi.org/10.26616/NIOSHPUB2015226
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Periodical
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  EID - Education and Information Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  22 pdf pages
• NIOSHTIC Number:
  nn:20046817
• NTIS Accession Number:
  PB2016-104191
• CAS Registry Number:
  Mevinphos (CAS RN 7786-34-7)
• Federal Fiscal Year:
  2015
• Peer Reviewed:
  False
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4e468f554f9b4a81518dd8a49fd25ce729d362696bf32ea7f9f435e3730f5e44181b5f062a9a58bc90921e742d9f59cbe4d6a9045d6c93ee602a92bf36860513
• Download URL:
  https://stacks.cdc.gov/view/cdc/36084/cdc_36084_DS1.pdf
• File Type:
  [PDF - 402.84 KB ]