NIOSH skin notation (SK) profile : Tetraethyl dithionopyrophosphate (TEDP) [CAS No. 3689-24-5]
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NIOSH skin notation (SK) profile : Tetraethyl dithionopyrophosphate (TEDP) [CAS No. 3689-24-5]

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    • Alternative Title:
      NIOSH skin notation profile
    • Description:
      As the largest organ of the body, the skin performs multiple critical functions, such as serving as the primary barrier to the external environment. For this reason, the skin is often exposed to potentially hazardous agents, including chemicals, which may contribute to the onset of a spectrum of adverse health effects ranging from localized damage (e.g., irritant contact dermatitis and corrosion) to induction of immune-mediated responses (e.g., allergic contact dermatitis and pulmonary responses), or systemic toxicity (e.g., neurotoxicity and hepatoxicity). Understanding the hazards related to skin contact with chemicals is a critical component of modern occupational safety and health programs.

      No in vivo or in vitro toxicokinetic data from humans or animals were identified for evaluating the potential of TEDP to be dermally absorbed; however, the mathematical model predicted that TEDP is absorbed through the skin. Acute toxicity data from animals [Scientific Associates 1950; Kimmerle and Klimmer 1974] indicate that TEDP is absorbed through the skin, is systemically available, and can be potentially fatal following dermal exposure. Acute dermal toxicity studies, with support from inhalation and oral studies, indicate that TEDP has the potential to cause ChE inhibition following repeated or prolonged dermal exposure [Kimmerle and Klimmer 1974]. The limited, conflicting data on direct skin effects [Scientific Associates 1950; Kimmerle and Klimmer 1974] do not allow for adequate evaluation of the potential for TEDP to cause skin irritation. No diagnostic (human patch) tests and no predictive tests in animals were identified that investigated the potential of TEDP to cause skin sensitization. Therefore, on the basis of these assessments, TEDP is assigned a composite skin notation of SK: SYS (FATAL).

      Suggested citation: NIOSH [2015]. NIOSH skin notation profile: Tetraethyl dithionopyrophosphate (TEDP). By Hudson NL, Dotson GS. Cincinnati, OH: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 2015-227.

      NIOSHTIC No 20046818


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