NIOSH Skin Notation (SK) Profile: Phorate [CAS No. 298-02-2]

Details

• Alternative Title:
  NIOSH skin notation profile
• Journal Article:
  National Institute for Occupational Safety and Health
• Personal Author:
  Hudson, Naomi L. ; Dotson, G. Scott
• Description:
  No studies were identified that estimated the degree of absorption of phorate through the skin following dermal exposure; however, the capacity of phorate to penetrate the skin can be inferred from the findings of acute toxicity studies in rats and is supported by the predictive algorithm for estimating and evaluating the health hazards of dermal exposure to chemical substances [NIOSH 2009]. The acute dermal toxicity studies in rats [Edson 1960; Gaines 1969] and an occupational exposure study [Kashyap et al. 1984] indicated phorate is highly toxic and potentially fatal in contact with skin, and it has the potential to cause systemic effects such as ChE inhibition, neurological and gastrointestinal effects, and lethality at low doses following dermal exposure. Although no standard skin irritation tests were identified for animals, a limited number of human patch tests did not indicate that phorate can cause direct skin effects or skin sensitization. Therefore, on the basis of these assessments, phorate is assigned a composite skin notation of SK: SYS (FATAL). Table 3 summarizes the skin hazard designations for phorate previously issued by NIOSH and other organizations. The equivalent dermal designation for phorate, according to the Globally Harmonized System (GHS) for the Classification and Labelling of Chemicals, is Acute Toxicity Category 1 (Hazard statement: Fatal in contact with the skin) [European Parliament 2008]. [Description provided by NIOSH]
• Subjects:
  Animals Cholinesterase Inhibitors Digestive System Digestive System Diseases Environmental Monitoring Epidemiology Hazardous Substances Insecticides Laboratories Nervous System Occupational Health Organophosphates Risk Assessment Risk Factors Safety Skin Toxicology

  More +
• Keywords:
  Skin-exposure; Skin; Exposure-levels; Risk-factors; Epidemiology; Toxicology; Acute-toxicity; Laboratory-animals; Animal-studies; Animals; Kinetics; Chemical-kinetics; Biological-systems; Dose-response; Lethal-dose; Pesticides; Organo-phosphorus-compounds; Organo-phosphorus-pesticides; Cholinesterase-inhibitors; Gastrointestinal-system; Gastrointestinal-system-disorders; Neurotoxic-effects; Neurotoxicity; Neurotoxins; Exposure-assessment; Dermal-exposure
• Source:
  Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 2015-230, 2015 Sep; :1-8
• Series:
  NIOSH Numbered Publications
• Subseries:
  Skin Notation Profile
• DOI:
  https://doi.org/10.26616/NIOSHPUB2015230
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Periodical
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  EID - Education and Information Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  22 pdf pages
• NIOSHTIC Number:
  nn:20046843
• NTIS Accession Number:
  PB2016-100075
• CAS Registry Number:
  Phorate (CAS RN 298-02-2)
• Federal Fiscal Year:
  2015
• Peer Reviewed:
  False
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:fea3649828c72536c0e89f150cb68200f1ab8f5d2705bc13929d72f498d0bf4a70e2c953505be3744568359d6e19bd3c1efda99b13e4a20cc8e78081d73916d4
• Download URL:
  https://stacks.cdc.gov/view/cdc/36080/cdc_36080_DS1.pdf
• File Type:
  [PDF - 394.17 KB ]