Details:

Alternative Title:
NIOSH skin notation profile
Personal Author:
Hudson, Naomi ; Dotson, G. Scott
Hudson, Naomi ; Dotson, G. Scott Less -
Corporate Authors:
National Institute for Occupational Safety and Health.
Description:
No studies were identified that estimated the degree of absorption of phorate through the skin following dermal exposure; however, the capacity of phorate to penetrate the skin can be inferred from the findings of acute toxicity studies in rats and is supported by the predictive algorithm for estimating and evaluating the health hazards of dermal exposure to chemical substances [NIOSH 2009]. The acute dermal toxicity studies in rats [Edson 1960; Gaines 1969] and an occupational exposure study [Kashyap et al. 1984] indicated phorate is highly toxic and potentially fatal in contact with skin, and it has the potential to cause systemic effects such as ChE inhibition, neurological and gastrointestinal effects, and lethality at low doses following dermal exposure. Although no standard skin irritation tests were identified for animals, a limited number of human patch tests did not indicate that phorate can cause direct skin effects or skin sensitization. Therefore, on the basis of these assessments, phorate is assigned a composite skin notation of SK: SYS (FATAL). Table 3 summarizes the skin hazard designations for phorate previously issued by NIOSH and other organizations. The equivalent dermal designation for phorate, according to the Globally Harmonized System (GHS) for the Classification and Labelling of Chemicals, is Acute Toxicity Category 1 (Hazard statement: Fatal in contact with the skin) [European Parliament 2008].

Suggested citation: NIOSH [2015]. NIOSH skin notation profile: Phorate. By Hudson NL, Dotson GS. Cincinnati, OH: U.S. Department of Health and Human Services, Centers for Disease Control and Pre- vention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 2015-230.

NIOSHTIC No 20046843

f15_snp_2015-230.pdf


Subject:
[+]
Dermatitis, Occupational
Environmental Exposure
Hazardous Substances/adverse Effects
Occupational Exposure
Phorate
Skin Absorption
Skin Diseases/chemically Induced

Series:
DHHS publication ; no. (NIOSH) 2015-230
Document Type:
Report
Collection(s):
Stephen B. Thacker CDC Library collection
Main Document Checksum:
[+]
urn:sha256:720e6bc181be238d44281748b3744c5ff96aa26fcd900d82c48fe9dc00cb0cdd
File Type:

Supporting Files

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