NIOSH Skin Notation (SK) Profile: Methyl parathion [CAS No. 298-00-0]

Details

• Alternative Title:
  NIOSH skin notation profile
• Journal Article:
  National Institute for Occupational Safety and Health
• Personal Author:
  Hudson, Naomi L. ; Dotson, G. Scott
• Description:
  The available toxicokinetic data from studies of methyl parathion absorption in humans [Muttray et al. 2010] and rats [Abu-Qare et al. 2000a, 2000b; Kramer et al. 2002] and from in vitro studies [Sartorelli et al. 1997; Van der Merwe and Riviere 2006] indicate that methyl parathion can be absorbed through the skin. Acute toxicity studies in rats [Gaines 1960], occupational exposure studies [Nemec et al. 1968; Ware et al. 1975; Wolff et al. 1992], and repeated-dose and subchronic toxicity studies in rats [Zhu et al. 2001; Ma et al. 2003] indicate the potential to cause systemic effects, including ChE inhibition, central nervous system effects, and lethality. No standard skin irritation tests were identified to evaluate the potential of methyl parathion to be a skin irritant. Human diagnostic patch tests indicate that methyl parathion is not likely to be a skin sensitizer. Therefore, on the basis of these assessments, methyl parathion is assigned a composite skin notation of SK: SYS (FATAL). Table 3 summarizes the skin hazard designations for methyl parathion previously issued by NIOSH and other organizations. The equivalent dermal designation for methyl parathion, according to the Globally Harmonized System (GHS) for the Classification and Labelling of Chemicals, is Acute Toxicity Category 3 (Hazard statement: Toxic in contact with the skin) [European Parliament 2008]. [Description provided by NIOSH]
• Subjects:
  Animals Cholinesterase Inhibitors Environmental Monitoring Epidemiology Hazardous Substances Insecticides Laboratories Nervous System Nervous System Disorders Occupational Health Organophosphates Risk Assessment Risk Factors Safety Skin Toxicology

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• Keywords:
  Skin-exposure; Skin; Exposure-levels; Risk-factors; Epidemiology; Toxicology; Acute-toxicity; Laboratory-animals; Animal-studies; Animals; Kinetics; Chemical-kinetics; Biological-systems; Dose-response; Lethal-dose; Pesticides; Organo-phosphorus-compounds; Organo-phosphorus-pesticides; Insecticides; Acetylcholinesterase; Cholinesterase-inhibitors; Methyl-compounds; Central-nervous-system; Central-nervous-system-disorders; Exposure-assessment; Dermal-exposure
• Source:
  Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 2015-231, 2015 Sep; :1-8
• Series:
  NIOSH Numbered Publications
• Subseries:
  Skin Notation Profile
• DOI:
  https://doi.org/10.26616/NIOSHPUB2015231
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Periodical
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  EID - Education and Information Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  24 pdf pages
• NIOSHTIC Number:
  nn:20046845
• NTIS Accession Number:
  PB2016-100076
• CAS Registry Number:
  Parathion-methyl (CAS RN 2Furfuryl alcohol (CAS RN 98-00-0))
• Federal Fiscal Year:
  2015
• Peer Reviewed:
  False
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:74996471fac2b9c5d28ce0da2de3395f5e70c13618f2fae61c32e022d487ba1e09a4d6f0939dbb55d8e9844e11fa6cbcf131677d336fd35bfe1e7f408f0f9a1c
• Download URL:
  https://stacks.cdc.gov/view/cdc/36079/cdc_36079_DS1.pdf
• File Type:
  [PDF - 415.71 KB ]