NIOSH Skin Notation (SK) Profile: Methyl parathion [CAS No. 298-00-0]

Details

• Alternative Title:
  NIOSH skin notation profile
• Personal Author:
  Dotson, G. Scott ; Hudson, Naomi L.
• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  The available toxicokinetic data from studies of methyl parathion absorption in humans [Muttray et al. 2010] and rats [Abu-Qare et al. 2000a, 2000b
  
  Kramer et al. 2002] and from in vitro studies [Sartorelli et al. 1997
  
  Van der Merwe and Riviere 2006] indicate that methyl parathion can be absorbed through the skin. Acute toxicity studies in rats [Gaines 1960], occupational exposure studies [Nemec et al. 1968
  
  Ware et al. 1975
  
  Wolff et al. 1992], and repeated-dose and subchronic toxicity studies in rats [Zhu et al. 2001
  
  Ma et al. 2003] indicate the potential to cause systemic effects, including ChE inhibition, central nervous system effects, and lethality. No standard skin irritation tests were identified to evaluate the potential of methyl parathion to be a skin irritant. Human diagnostic patch tests indicate that methyl parathion is not likely to be a skin sensitizer. Therefore, on the basis of these assessments, methyl parathion is assigned a composite skin notation of SK: SYS (FATAL). Table 3 summarizes the skin hazard designations for methyl parathion previously issued by NIOSH and other organizations. The equivalent dermal designation for methyl parathion, according to the Globally Harmonized System (GHS) for the Classification and Labelling of Chemicals, is Acute Toxicity Category 3 (Hazard statement: Toxic in contact with the skin) [European Parliament 2008].
  
  Suggested citation: NIOSH [2015]. NIOSH skin notation profile: Methyl parathion By Hudson NL, Dotson GS. Cincinnati, OH: U.S. Department of Health and Human Services, Centers for Disease Control and Pre- vention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 2015-231.
  
  NIOSHTIC No 20046845
  
  f15_snp_2015-231.pdf
  
  
• Subjects:
  Occupational Health Safety
• Series:
  NIOSH Numbered Publications
• DOI:
  https://doi.org/10.26616/NIOSHPUB2015231
• Document Type:
  Text
• Genre:
  Report
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  8 numbered pages
• NIOSHTIC Number:
  nn:20046845
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:74996471fac2b9c5d28ce0da2de3395f5e70c13618f2fae61c32e022d487ba1e09a4d6f0939dbb55d8e9844e11fa6cbcf131677d336fd35bfe1e7f408f0f9a1c
• Download URL:
  https://stacks.cdc.gov/view/cdc/36079/cdc_36079_DS1.pdf
• File Type:
  [PDF - 415.71 KB ]