NIOSH skin notation (SK) profile : Parathion [CAS No. 56-38-2]
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NIOSH skin notation (SK) profile : Parathion [CAS No. 56-38-2]

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    • Alternative Title:
      NIOSH skin notation profile
    • Description:
      The available toxicokinetic data from both humans and animals in in vivo studies [Maibach et al. 1971; Feldmann and Maibach 1974; Shah and Guthrie 1983; Knaak et al. 1984; Carver and Riviere 1989; Gyrd-Hansen and Rasmussen 1993; Qiao et al. 1993] and in vitro studies [Shehata-Karam et al., 1988; Chang and Riviere 1991, 1993; van der Merwe and Riviere 2005, 2006; van der Merwe et al. 2006; Moody et al. 2007 Boudry et al. 2008; Miller and Kasting 2010] and from acute dermal toxicity studies in animals [Gaines 1960; Pasquet et al. 1976], supported by the case report describing a human fatality following repeated dermal exposure to parathion [Grob et al. 1949], provide sufficient evidence that parathion can penetrate the skin and be absorbed in sufficient quantities to be fatal following acute dermal exposure. Although no standard skin irritation tests were identified, a repeated-dose study [Dikshith and Datta 1972] indicated that parathion has the potential to cause skin irritation and skin damage, but the damage was revealed only on microscopic examination. Therefore, on the basis of these assessments, parathion is assigned a composite skin notation of SK: SYS (FATAL). Table 3 summarizes the skin hazard designations for parathion previously issued by NIOSH and other organizations. The equivalent dermal designation for parathion, according to the Globally Harmonized System (GHS) for the Classification and Labelling of Chemicals, is Acute Toxicity Category 3 (Hazard statement: Toxic in contact with the skin) [European Parliament 2008]. Suggested citation: NIOSH [2015]. NIOSH skin notation profile: Parathion. By Hudson NL, Dotson GS. Cincin- nati, OH: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 2015-232. NIOSHTIC No 20046847 f15_snp_2015-232.pdf
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