NIOSH Skin Notation (SK) Profile: Azinphos-methyl [CAS No. 86-50-0]

Details

• Alternative Title:
  NIOSH skin notation profile
• Personal Author:
  Dotson, G. Scott ; Hudson, Naomi L.
• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  There is sufficient data from toxicokinetic studies in humans [Feldman and Maibach 1974
  
  Wester et al. 1985
  
  Franklin et al. 1989
  
  McCurdy et al. 1994] and animals [Franklin et al. 1989
  
  Thongsinthusack 1999] to demonstrate that azinphos-methyl can be absorbed through the skin and is systemically available. Acute dermal toxicity data from animals [Gains 1960
  
  Sato 1959
  
  Pasquet et al. 1976] and a case report [Quinby et al. 1958] indicate that azinphos-methyl can be fatal following exposure at low doses. No prolonged, repeated-dose dermal toxicity studies were identified, but azinphos-methyl inhibits AChE in the central and peripheral nervous systems, as is observed in oral toxicity studies in rats [Sheets 1994]. No case reports or standard skin irritation tests in animals were identified for determining the potential of azinphos-methyl to cause direct skin effects. No diagnostic tests in humans or case reports of sensitization were identified, but a well-conducted Buehler patch test on guinea pigs indicates that azinphos-methyl has the potential to cause skin sensitization [Bayer AG 1987]. Therefore, on the basis of these assessments, azinphos-methyl is assigned a composite skin notation of SK: SYS (FATAL)-SEN. Table 3 summarizes the skin hazard designations for azinphos-methyl previously issued by NIOSH and other organizations. The equivalent dermal designations for azinphos-methyl, according to the Globally Harmonized System (GHS) for the Classification and Labelling of Chemicals, are Acute Toxicity Category 3 (Hazard statement: Toxic in contact with the skin) and Skin Sensitization Category 1 (Hazard statement: May cause an allergic skin reaction) [European Parliament 2008].
  
  Suggested citation: NIOSH [2015]. NIOSH [2015]. NIOSH skin notation profile: Azinphos-methyl. By Hudson NL, Dotson GS. Cincinnati, OH: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publi- cation No. 2015-235.
  
  NIOSHTIC No 20046851
  
  f15_snp_2015-235.pdf
  
  
• Subjects:
  Nicotine Occupational Health Safety
• Series:
  NIOSH Numbered Publications
• DOI:
  https://doi.org/10.26616/NIOSHPUB2015235
• Document Type:
  Text
• Genre:
  Report
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  9 numbered pages
• NIOSHTIC Number:
  nn:20046851
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a486c6bbc6b6a581f0032b540a2e8e081bbd2a1fec5ecadedb3ee4c7f065f865546bc06785c6c9ededb5fb18443279db0ce6220a44b860e2d35be74d4431e53c
• Download URL:
  https://stacks.cdc.gov/view/cdc/36075/cdc_36075_DS1.pdf
• File Type:
  [PDF - 405.81 KB ]