Opportunities to reduce overuse of antibiotics for perinatal group B streptococcal disease prevention and management of preterm premature rupture of membranes.

Details

• Alternative Title:
  Infect Dis Obstet Gynecol
• Personal Author:
  Glass, Nina E. ; Schulkin, Jay ; Chamany, Shadi ; Riley, Laura E. ; Schuchat, Anne ; Schrag, Stephanie
• Description:
  To identify opportunities to reduce overuse of antibiotics for prevention of perinatal group B streptococcal (GBS) disease and management of preterm premature rupture of membranes (pPROM).|An anonymous written questionnaire was sent to each of 1031 Fellows of the American College of Obstetricians and Gynecologists, and the responses were subjected to statistical analysis.|Among those of the 404 respondents who saw obstetric patients in 2001, most (84%) screened for GBS colonization, and 22% of these prescribed prenatal antibiotics to try to eradicate GBS colonization. Of the 382 respondents (95%) who prescribed antibiotics for pPROM, 36% continued antibiotics for more than 7 days despite negative results from GBS cultures collected before initiation of treatment. Having more years of clinical experience (adjusted odds ratio (OR) 3.0, 95% confidence interval (CI) 1.5 to 6.2), working in a non-academic setting (adjusted OR 2.7, 95% CI 1.0 to 6.9), and prescribing antibiotics prenatally for GBS colonization (adjusted OR 2.0, 95% CI 1.1 to 3.4) were associated with prescribing prolonged antibiotics for pPROM.|Prenatal antibiotic treatment for GBS colonization and prolonged antibiotic treatment for pPROM contribute to overuse of antibiotics in obstetrics.
• Subjects:
  Antibiotic Prophylaxis Female Fetal Membranes, Premature Rupture Humans Infant, Newborn Male Multivariate Analysis Obstetric Labor, Premature Physician's Practice Patterns Pregnancy Pregnancy Complications, Infectious Questionnaires Research Article Streptococcal Infections

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• Source:
  Infect Dis Obstet Gynecol. 13(1):5-10.
• Document Type:
  Journal Article
• Volume:
  13
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:895c84ea7b2241a29fa9758acbbc2a5af87791812f83aa9c984a84faabfb223e41f08f0d5fed42db198ba47aa99c68a16b8f6cb5a901bdc47f265e98aa81591f
• Download URL:
  https://stacks.cdc.gov/view/cdc/3595/cdc_3595_DS1.pdf
• File Type:
  [PDF - 72.40 KB ]