Public Health Impact After the Introduction of PsA-TT: The First 4 Years

Details

• Alternative Title:
  Clin Infect Dis
• Personal Author:
  Diomandé, Fabien V. K. ; Djingarey, Mamoudou H. ; Daugla, Doumagoum M. ; Novak, Ryan T. ; Kristiansen, Paul A. ; Collard, Jean-Marc ; Gamougam, Kadidja ; Kandolo, Denis ; Mbakuliyemo, Nehemie ; Mayer, Leonard ; Stuart, James ; Clark, Thomas ; Tevi-Benissan, Carol ; Perea, William A. ; Preziosi, Marie-Pierre ; Marc LaForce, F. ; Caugant, Dominique ; Messonnier, Nancy ; Walker, Oladapo ; Greenwood, Brian
• Description:
  During the first introduction of a group A meningococcal vaccine (PsA-TT) in 2010-2011 and its rollout from 2011 to 2013, >150 million eligible people, representing 12 hyperendemic meningitis countries, have been vaccinated.|The new vaccine effectiveness evaluation framework was established by the World Health Organization and partners. Meningitis case-based surveillance was strengthened in PsA-TT first-introducer countries, and several evaluation studies were conducted to estimate the vaccination coverage and to measure the impact of vaccine introduction on meningococcal carriage and disease incidence.|PsA-TT implementation achieved high vaccination coverage, and results from studies conducted showed significant decrease of disease incidence as well as significant reduction of oropharyngeal carriage of group A meningococci in vaccinated and unvaccinated individuals, demonstrating the vaccine's ability to generate herd protection and prevent group A epidemics.|Lessons learned from this experience provide useful insights in how to guide and better prepare for future new vaccine introductions in resource-limited settings.
• Subjects:
  Adolescent Adult Carrier State Child Child, Preschool Disease Transmission, Infectious Female Humans Incidence Infant Male Meningococcal Infections Meningococcal Vaccines Treatment Outcome Young Adult

  More +
• Source:
  Clin Infect Dis. 2015; 61(Suppl 5):S467-S472.
• Pubmed ID:
  26553676
• Pubmed Central ID:
  PMC4639484
• Document Type:
  Journal Article
• Place as Subject:
  Africa
• Volume:
  61
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:e0fe2e9d7eccf0679588de14e5f7ba9a064b4fc7834243ec92cd3254fd620210
• Download URL:
  https://stacks.cdc.gov/view/cdc/35775/cdc_35775_DS1.pdf
• File Type:
  [PDF - 175.59 KB ]