Details:

Alternative Title:
PLoS One
Personal Author:
Contreras, Carmen Lucía ; Verani, Jennifer R. ; Lopez, María Renee ; Paredes, Antonio ; Bernart, Chris ; ... More +
Contreras, Carmen Lucía ; Verani, Jennifer R. ; Lopez, María Renee ; Paredes, Antonio ; Bernart, Chris ; Moscoso, Fabiola ; Roldan, Aleida ; Arvelo, Wences ; Lindblade, Kim A. ; McCracken, John P. Less -
Description:
Background

Streptococcus pneumoniae is a leading cause of pneumonia worldwide. However, the burden of pneumococcal pneumonia among adults in low- and middle-income countries is not well described.

Methods

Data from 2008–2012 was analyzed from two surveillance sites in Guatemala to describe the incidence of pneumococcal pneumonia in adults. A case of hospitalized pneumococcal pneumonia was defined as a positive pneumococcal urinary antigen test or blood culture in persons aged ≥ 18 years hospitalized with an acute respiratory infection (ARI).

Results

Among 1595 adults admitted with ARI, 1363 (82%) had either urine testing (n = 1286) or blood culture (n = 338) performed. Of these, 188 (14%) had pneumococcal pneumonia, including 173 detected by urine only, 8 by blood culture only, and 7 by both methods. Incidence rates increased with age, with the lowest rate among 18–24 year-olds (2.75/100,000) and the highest among ≥65 year-olds (31.3/100,000). The adjusted incidence of hospitalized pneumococcal pneumonia was 18.6/100,000 overall, with in-hospital mortality of 5%.

Conclusions

An important burden of hospitalized pneumococcal pneumonia in adults was described, particularly for the elderly. However, even adjusted rates likely underestimate the true burden of pneumococcal pneumonia in the community. These data provide a baseline against which to measure the indirect effects of the 2013 introduction of the pneumococcal conjugate vaccine in children in Guatemala.


Subjects:
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Adolescent Adult Aged Antigens, Bacterial Female Hospitalization Hospital Mortality Humans Incidence Male Middle Aged Pneumococcal Vaccines Pneumonia, Pneumococcal Streptococcus Pneumoniae Young Adult
Source:
PLoS One. 10(10).
Pubmed ID:
26488871
Pubmed Central ID:
PMC4619266
Document Type:
Journal Article
Place as Subject:
Guatemala
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:153c688aa76d91e5154b1730603e75e6838fde37a8329e7340d8746d18f7ab67
Download URL:
https://stacks.cdc.gov/view/cdc/35513/cdc_35513_DS1.pdf
File Type:

Supporting Files

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