Transmission of Methicillin-Resistant Staphylococcus aureus Infection Through Solid Organ

Details

• Alternative Title:
  Am J Transplant
• Personal Author:
  Wendt, J. M. ; Kaul, D. ; Limbago, B. M. ; Ramesh, M. ; Cohle, S. ; Denison, A. M. ; Driebe, E. M. ; Rasheed, J. K. ; Zaki, S. R. ; Blau, D. M. ; Paddock, C. D. ; McDougal, L. K. ; Engelthaler, D. M. ; Keim, P. S. ; Roe, C. C. ; Akselrod, H. ; Kuehnert, M. J. ; Basavaraju, S. V.
• Description:
  We describe two cases of donor-derived methicillin-resistant Staphylococcus aureus (MRSA) bacteremia that developed after transplantation of organs from a common donor who died from acute MRSA endocarditis. Both recipients developed recurrent MRSA infection despite appropriate antibiotic therapy, and required prolonged hospitalization and hospital readmission. Comparison of S. aureus whole genome sequence of DNA extracted from fixed donor tissue and recipients' isolates confirmed donor-derived transmission. Current guidelines emphasize the risk posed by donors with bacteremia from multidrug-resistant organisms. This investigation suggests that, particularly in the setting of donor endocarditis, even a standard course of prophylactic antibiotics may not be sufficient to prevent donor-derived infection.
• Subjects:
  Article DNA, Bacterial Genome, Bacterial Humans Male Methicillin-Resistant Staphylococcus Aureus Organ Transplantation Polymorphism, Single Nucleotide Sequence Analysis, DNA Staphylococcal Infections Tissue Donors

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• Source:
  Am J Transplant. 14(11):2633-2639.
• Pubmed ID:
  25250717
• Pubmed Central ID:
  PMC4620542
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States
• Volume:
  14
• Issue:
  11
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:ba20d342bd1c7d941eacc3ea8042e6df7391945db83092674189eb7302863138
• Download URL:
  https://stacks.cdc.gov/view/cdc/35344/cdc_35344_DS1.pdf
• File Type:
  [PDF - 926.40 KB ]