A varicella outbreak in a school with high one-dose vaccination coverage, Beijing, China☆
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A varicella outbreak in a school with high one-dose vaccination coverage, Beijing, China☆

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  • English
    • Details Supporting Files You May Also Like

    Details:

    • Alternative Title:
      Vaccine
    • Publisher's site:
      http://dx.doi.org/10.1016/j.vaccine.2012.05.072
    • Personal Author:
    • Description:
      Background

      Varicella vaccine is available in the private sector in China, with a single dose currently recommended for children aged ≥12 months. We investigated a varicella outbreak in a school in Beijing with high varicella vaccination coverage to describe the outbreak, examine risk factors for vaccine failure, and calculate vaccine effectiveness.

      Methods

      A varicella case was defined as an acute generalized maculopapular rash without other apparent cause in a student without prior varicella attending the elementary school during August 30–December 28, 2010. Varicella among vaccinated students (breakthrough varicella) was defined as varicella occurring >42 days after vaccination. Students’ vaccination status was verified with immunization records and clinical presentations were collected from health care practitioners.

      Results

      Of the 951 students, 934 (98%) had no prior varicella history. Among these students, 916 had received 1 dose of varicella vaccine and 2 had received 2 doses (98% vaccination coverage) before the outbreak. A total of 87 cases occurred during the outbreak; most had breakthrough varicella (86/87, 99%) and mild disease (83/87, 95%). Age at vaccination (<15 months vs.≥15 months) and time since vaccination before outbreak (<5 years vs. ≥5 years) were not associated with development of breakthrough varicella. Single-dose varicella vaccination was 89% effective in preventing any varicella and 99% in preventing moderate/severe varicella.

      Conclusion

      Single-dose varicella vaccination is highly effective in reducing varicella incidence and mitigating disease severity, but not high enough to prevent outbreak. A two-dose program might help to prevent varicella outbreaks in Beijing.

    • Subject:
    • Source:
      Vaccine. 30(34):5094-5098.
    • Pubmed ID:
      22687763
    • Pubmed Central ID:
      PMC4620431
    • Document Type:
      Journal Article
    • Funding:
      CC999999/Intramural CDC HHS/United States
    • Place as Subject:
      China
    • Collection(s):
      CDC Public Access
    • Main Document Checksum:
    • File Type:

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