Safety of Tetanus, Diphtheria, and Acellular Pertussis and Influenza Vaccinations in Pregnancy

Details

• Alternative Title:
  Obstet Gynecol
• Personal Author:
  Sukumaran, Lakshmi ; McCarthy, Natalie L. ; Kharbanda, Elyse O. ; Weintraub, Eric ; Vazquez-Benitez, Gabriela ; McNeil, Michael M. ; Li, Rongxia ; Klein, Nicola P. ; Hambidge, Simon J. ; Naleway, Allison L. ; Lugg, Marlene M. ; Jackson, Michael L. ; King, Jennifer P. ; DeStefano, Frank ; Omer, Saad B. ; Orenstein, Walter A.
• Description:
  Objective
  
  To evaluate the safety of co-administering tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) and influenza vaccines during pregnancy by comparing adverse events after concomitant and sequential vaccination.
  
  Methods
  
  We conducted a retrospective cohort study of pregnant women aged 14–49 years in the Vaccine Safety Datalink from January 1, 2007 to November 15, 2013. We compared medically attended acute events (fever, any acute reaction) and adverse birth outcomes (preterm delivery, low birth weight, small for gestational age) in women receiving concomitant Tdap and influenza vaccination and women receiving sequential vaccination.
  
  Results
  
  Among 36,844 pregnancies in which Tdap and influenza vaccines were administered, the vaccines were administered concomitantly in 8,464 (23%) pregnancies, and sequentially in 28,380 (77%) pregnancies. Acute adverse events after vaccination were rare. We found no statistically significant increased risk of fever or any medically attended acute adverse event in pregnant women vaccinated concomitantly compared to sequentially. When analyzing women at 20 weeks of gestation or greater during periods of influenza vaccine administration, there were no differences in preterm delivery, low birth weight or small-for-gestational-age infants between women vaccinated concomitantly compared with sequentially in pregnancy.
  
  Conclusion
  
  Concomitant administration of Tdap and influenza vaccines during pregnancy was not associated with a higher risk of medically attended adverse acute outcomes or birth outcomes compared to sequential vaccination.
  
  
• Subjects:
  Adolescent Adult Article Diphtheria-Tetanus-acellular Pertussis Vaccines Female Humans Influenza Vaccines Middle Aged Pregnancy Pregnancy Complications Retrospective Studies Young Adult

  More +
• Source:
  Obstet Gynecol. 126(5):1069-1074.
• Pubmed ID:
  26444109
• Pubmed Central ID:
  PMC4618722
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States ; T32 AI074492/AI/NIAID NIH HHS/United States
• Volume:
  126
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:8a19c9d57bbd795b7d81f5495e5e8785059b844d5a49d1089f3e3f51b6f46622
• Download URL:
  https://stacks.cdc.gov/view/cdc/35335/cdc_35335_DS1.pdf
• File Type:
  [PDF - 256.13 KB ]