Details:

Alternative Title:
Part Fibre Toxicol
Publisher's site:
http://dx.doi.org/10.1186/s12989-015-0106-4
Personal Author:
Konduru, Nagarjun V. ; Jimenez, Renato J. ; Swami, Archana ; Friend, Sherri ; Castranova, Vincent ; ... More +
Konduru, Nagarjun V. ; Jimenez, Renato J. ; Swami, Archana ; Friend, Sherri ; Castranova, Vincent ; Demokritou, Philip ; Brain, Joseph D. ; Molina, Ramon M. Less -
Description:
Background

The physicochemical properties of nanoparticles (NPs) influence their biological outcomes.

Methods

We assessed the effects of an amorphous silica coating on the pharmacokinetics and pulmonary effects of CeO2 NPs following intratracheal (IT) instillation, gavage and intravenous injection in rats. Uncoated and silica-coated CeO2 NPs were generated by flame spray pyrolysis and later neutron-activated. These radioactive NPs were IT-instilled, gavaged, or intravenously (IV) injected in rats. Animals were analyzed over 28 days post-IT, 7 days post-gavage and 2 days post-injection.

Results

Our data indicate that silica coating caused more but transient lung inflammation compared to uncoated CeO2. The transient inflammation of silica-coated CeO2 was accompanied by its enhanced clearance. Then, from 7 to 28 days, clearance was similar although significantly more 141Ce from silica-coated (35 %) was cleared than from uncoated (19 %) 141CeO2 in 28 days. The protein coronas of the two NPs were significantly different when they were incubated with alveolar lining fluid. Despite more rapid clearance from the lungs, the extrapulmonary 141Ce from silica-coated 141CeO2 was still minimal (<1 %) although lower than from uncoated 141CeO2 NPs. Post-gavage, nearly 100 % of both NPs were excreted in the feces consistent with very low gut absorption. Both IV-injected 141CeO2 NP types were primarily retained in the liver and spleen. The silica coating significantly altered the plasma protein corona composition and enhanced retention of 141Ce in other organs except the liver.

Conclusion

We conclude that silica coating of nanoceria alters the biodistribution of cerium likely due to modifications in protein corona formation after IT and IV administration.


Subject:
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Bioavailability
Nanoceria
Protein Corona
Research
Silica

Source:
Part Fibre Toxicol. 12.
Pubmed ID:
26458946
Pubmed Central ID:
PMC4603643
Document Type:
Journal Article
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:8024b6381f89d2f346b1d895e921b8350bf3fb2a73d181775470cea66576de3c
File Type:

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