Details:

Alternative Title:
Pediatr Infect Dis J
Publisher's site:
http://dx.doi.org/10.1097/INF.0000000000000821
Personal Author:
Leung, Jessica ; Lopez, Adriana S. ; Blostein, Joel ; Thayer, Nancy ; Zipprich, Jennifer ; ... More +
Leung, Jessica ; Lopez, Adriana S. ; Blostein, Joel ; Thayer, Nancy ; Zipprich, Jennifer ; Clayton, Anna ; Buttery, Vicki ; Andersen, Jannifer ; Thomas, Carrie A. ; del Rosario, Maria ; Seetoo, Kurt ; Woodall, Tracy ; Wiseman, Rachel ; Bialek, Stephanie R. Less -
Description:
Background

A routine 2-dose varicella vaccination program was adopted in 2007 in the United States to help further decrease varicella disease and prevent varicella outbreaks. We describe trends and characteristics of varicella outbreaks reported to CDC during 2005–2012 from 9 states.

Methods

Data on varicella outbreaks collected by 9 state health departments were submitted to CDC using the CDC outbreak reporting worksheet. Information was collected on dates of the outbreak, outbreak setting, and number of cases by outbreak; aggregate data was provided on the numbers of outbreak-related cases by age group, vaccination status, and laboratory confirmation.

Results

Nine hundred and twenty-nine outbreaks were reported from the 6 states which provided data for each year during 2005–2012. Based on data from these 6 states, the number of outbreaks declined by 78%, decreasing from 147 in 2005 to 33 outbreaks in 2012 (p=0.0001). There were a total of 1,015 varicella outbreaks involving 13,595 cases reported by the 9 states from 2005–2012. The size and duration of outbreaks declined significantly over time (p<0.001). The median size of outbreaks was 12, 9, and 7 cases and median duration of outbreaks was 38, 35, and 26 days during 2005–2006, 2007–2009, and 2010–2012 respectively. Majority of outbreaks (95%) were reported from schools, declining from 97% in 2005–2006 to 89% in 2010–2012. Sixty-five percent of outbreak-related cases occurred among 5–9 year olds, with the proportion declining from 76% in 2005–2006 to 45% during 2010–2012.

Conclusions

The routine 2-dose varicella vaccination program appears to have significantly reduced the number, size, and duration of varicella outbreaks in the U.S.


Subject:
[+]
Adolescent
Adult
Article
Chickenpox
Chickenpox Vaccine
Child
Child, Preschool
Disease Outbreaks
Humans
Infant
Infant, Newborn
Mass Vaccination
Retrospective Studies
Young Adult

Source:
Pediatr Infect Dis J. 34(10):1105-1109.
Pubmed ID:
26186103
Pubmed Central ID:
PMC4606850
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Place as Subject:
United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:9f82f2acf37f1030bf4c0760e7e4caff85ac01b79ab8661981d7b47e0a23459b
File Type:

Supporting Files

• 	NIHMS727046-supplement-supplement_1.pdf	pdf
  	nihms727046.nxml	bin
  	nihms727046f1.gif	gif
  	nihms727046f1.jpg	jpeg

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