Effectiveness of typhoid vaccination in US travelers

Details

• Alternative Title:
  Vaccine
• Personal Author:
  Mahon, Barbara E. ; Newton, Anna E. ; Mintz, Eric D.
• Description:
  Typhoid vaccination is recommended in the United States before travel to countries where typhoid fever is endemic, though little information is available on its effectiveness in travelers. We estimated typhoid vaccination effectiveness (VE) by comparing vaccination status in cases of typhoid fever and paratyphoid fever (Salmonella Paratyphi A infection, against which typhoid vaccine offers no protection) reported in the United States. We included travelers to Southern Asia and excluded persons <2 years old and cases in which vaccination status was not reported. From 2008 through 2011, 744 eligible cases (602 typhoid, 142 paratyphoid A) were reported to CDC. Typhoid vaccination was reported for 5% (29/602) of typhoid patients and for 20% (29/142) of paratyphoid A patients. Estimated VE was 80% (95% confidence interval, 66-89%). Because of missing data, we could not estimate VE for specific vaccines. We demonstrated moderate effectiveness of typhoid vaccination in US travelers, supporting vaccination recommendations.
• Subjects:
  Adolescent Adult Aged Aged, 80 And Over Child Child, Preschool Female Humans Logistic Models Male Middle Aged Odds Ratio Paratyphoid Fever Sentinel Surveillance Travel Typhoid-Paratyphoid Vaccines Typhoid Fever Vaccination Young Adult

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• Keywords:
  Travelers Typhoid Vaccination United States Vaccination Effectiveness
• Source:
  Vaccine. 32(29):3577-3579
• Pubmed ID:
  24837780
• Pubmed Central ID:
  PMC4604742
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHSUnited States/
• Name as Subject:
  Centers for Disease Control and Prevention (U.S.)
• Place as Subject:
  United States
• Volume:
  32
• Issue:
  29
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:301eda2450d4964a283f3850adfe35a41b4b7c1d24101e89d483ec5ff6251abb
• Download URL:
  https://stacks.cdc.gov/view/cdc/34956/cdc_34956_DS1.pdf
• File Type:
  [PDF - 79.97 KB ]