Does the association of the triglyceride to high-density lipoprotein cholesterol ratio with fasting serum insulin differ by race/ethnicity?

Details

• Alternative Title:
  Cardiovasc Diabetol
• Personal Author:
  Li, Chaoyang ; Ford, Earl S ; Meng, Yuan-Xiang ; Mokdad, Ali H ; Reaven, Gerald M
• Description:
  Background
  
  The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio has been reported to be as closely correlated with insulin resistance as is the fasting serum insulin concentration (FSI), and therefore it is seen as a clinically useful way to identify the concomitant presence of insulin resistance and dyslipidemia. However, conflicting findings exist for the association of the TG/HDL-C ratio with FSI by race/ethnicity.
  
  Methods
  
  The associations of FSI concentration, serum triglyceride concentrations, and HDL-C were analyzed using log-binomial regression analyses and receiver operating characteristic (ROC) curve analysis among nondiabetic adults (n = 2652, aged ≥ 20 years, 51.2% men) in the United States.
  
  Results
  
  After adjustment for potential confounding effects, the prevalence ratio of hyperinsulinemia was 2.16 (95% confidence interval [CI], 1.74 to 2.08) when using a single cutoff point of 3.5, and 2.23 (95% CI, 1.83 to 2.72) when using race/ethnicity-specific cutoff points of 3.0 for non-Hispanic whites and Mexican Americans and 2.0 for non-Hispanic blacks for the TG/HDL-C ratio. The area under the ROC curve of the TG/HDL-C ratio for predicting hyperinsulinemia was 0.77 (95% CI, 0.74 to 0.79), 0.75 (95% CI, 0.69 to 0.77), and 0.74 (95% CI, 0.69 to 0.76) for non-Hispanic whites, non-Hispanic blacks, and Mexican Americans, respectively.
  
  Conclusion
  
  There was a significant association between the TG/HDL-C ratio and FSI among three major racial/ethnic groups in the United States. Our results add further support to the notion that the TG/HDL-C ratio may be a clinically simple and useful indicator for hyperinsulinemia among nondiabetic adults regardless of race/ethnicity.
  
  
• Subjects:
  Adult Black Or African American Cholesterol, HDL Fasting Female Humans Hyperinsulinism Insulin Insulin Resistance Logistic Models Male Mexican Americans Prevalence ROC Curve Triglycerides White People

  More +
• Source:
  Cardiovasc Diabetol. 2008; 7:4.
• Document Type:
  Journal Article
• Place as Subject:
  United States
• Volume:
  7
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:af94102deb0aa8e617c5ba69e7b440b45f1e7298c3f4bf18fc057ddee40216a8
• Download URL:
  https://stacks.cdc.gov/view/cdc/3487/cdc_3487_DS1.pdf
• File Type:
  [PDF - 306.29 KB ]