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Gene length matters in neurons
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Apr 22 2015
Source: Neuron. 86(2):353-355. -
Alternative Title:Neuron
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Personal Author:
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Description:A recent study by Gabel et al. (2015) found that Mecp2, the gene mutated in Rett syndrome, represses long (> 100 kb) genes associated with neuronal physiology and connectivity by binding to methylated CA sites in DNA. This study adds to a growing body of literature implicating gene length and transcriptional mechanisms in neurodevelopmental and neurodegenerative disorders.
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Pubmed ID:25905808
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Pubmed Central ID:PMC4584405
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