Gene length matters in neurons

Details

• Alternative Title:
  Neuron
• Personal Author:
  Zylka, Mark J. ; Simon, Jeremy M. ; Philpot, Benjamin D.
• Description:
  A recent study by Gabel et al. (2015) found that Mecp2, the gene mutated in Rett syndrome, represses long (> 100 kb) genes associated with neuronal physiology and connectivity by binding to methylated CA sites in DNA. This study adds to a growing body of literature implicating gene length and transcriptional mechanisms in neurodevelopmental and neurodegenerative disorders.
• Subjects:
  Animals Article DNA Methylation Female Humans Male Methyl-CpG-Binding Protein 2 Mutation Rett Syndrome
• Source:
  Neuron. 86(2):353-355.
• Pubmed ID:
  25905808
• Pubmed Central ID:
  PMC4584405
• Document Type:
  Journal Article
• Funding:
  DP1 ES024088/ES/NIEHS NIH HHS/United States ; DP1ES024088/DP/NCCDPHP CDC HHS/United States ; P30 NS045892/NS/NINDS NIH HHS/United States ; P30NS045892/NS/NINDS NIH HHS/United States ; R01 MH093372/MH/NIMH NIH HHS/United States ; R01MH093372/MH/NIMH NIH HHS/United States ; U54 HD079124/HD/NICHD NIH HHS/United States ; U54HD079124/HD/NICHD NIH HHS/United States
• Volume:
  86
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:79c3659947858ebbd943284a0d46b4fb9ee20044209c465867b1701dd161c58d
• Download URL:
  https://stacks.cdc.gov/view/cdc/34530/cdc_34530_DS1.pdf
• File Type:
  [PDF - 510.69 KB ]