Details:

Alternative Title:
Anal Chem
Publisher's site:
http://dx.doi.org/10.1021/ac400077e
Personal Author:
Lisko, Joseph G. ; Stanfill, Stephen B. ; Duncan, Bryce W. ; Watson, Clifford H.
Lisko, Joseph G. ; Stanfill, Stephen B. ; Duncan, Bryce W. ; Watson, Clifford H. Less -
Description:
This publication reports the first known use of gas chromatography-tandem mass spectrometry for the quantitation of five minor tobacco alkaloids (nornicotine, myosmine, anabasine, anatabine, and isonicoteine) in various tobacco samples. A summary of the concentrations of these minor alkaloid levels in the filler from 50 popular cigarette brands were found to be 659-986 μg/g nornicotine, 8.64-17.3 μg/g myosmine, 127-185 μg/g anabasine, 927-1390 μg/g anatabine, and 23.4-45.5 μg/g isonicoteine. Levels of minor alkaloids found in reference cigarettes (1R5F, 2R4F, 3R4F, CM4, and CM6) as well as burley, flue-cured, oriental, reconstituted, and Nicotiana rustica and Nicotiana glauca tobacco types are also reported. Quantitation of the minor tobacco alkaloids is important because the alkaloids have been shown to be precursors of carcinogenic tobacco specific N'-nitrosamines.
Subject:
[+]
Alkaloids
Anabasine
Anatabine
Article
Gas Chromatography-Mass Spectrometry
GC-MS/MS
Isonicoteine
Myosmine
Nornicotine
Tandem Mass Spectrometry
Tobacco
Tobacco Products

Source:
Anal Chem. 85(6):3380-3384.
Pubmed ID:
23394466
Pubmed Central ID:
PMC4573525
Document Type:
Journal Article
Funding:
IVV0/Intramural CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:022c54e98b53b3241314ebff4bce4bcba97cef674584aafbdc30fc799f3bde18
File Type:

Supporting Files

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