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Reproductive Health Risks Associated with Occupational Exposures to Antineoplastic Drugs in Health Care Settings: A Review of the Evidence
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9 2014
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Source: J Occup Environ Med. 56(9):901-910
[PDF-217.31 KB]
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Alternative Title:J Occup Environ Med
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Description:Objectives
Antineoplastic drugs are known reproductive and developmental toxicants. Our objective was to review the existing literature of reproductive health risks to workers who handle antineoplastic drugs.
Methods
A structured literature review of 18 peer-reviewed, English language publications of occupational exposure and reproductive outcomes was performed.
Results
While effect sizes varied with study size and population, occupational exposure to antineoplastic drugs appears to raise the risk of both congenital malformations and miscarriage. Studies of infertility and time-to-pregnancy also suggested an increased risk for sub-fertility.
Conclusions
Antineoplastic drugs are highly toxic in patients receiving treatment and adverse reproductive effects have been well documented in these patients. Healthcare workers with chronic, low level occupational exposure to these drugs also appear to have an increased risk of adverse reproductive outcomes. Additional precautions to prevent exposure should be considered.
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Pubmed ID:25153300
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Pubmed Central ID:PMC4569003
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Volume:56
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Issue:9
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