Details:

Alternative Title:
Occup Environ Med
Publisher's site:
http://dx.doi.org/10.1136/oemed-2012-100906
Personal Author:
Daniels, Robert D. ; Bertke, Stephen ; Waters, Kathleen M. ; Schubauer-Berigan, Mary K.
Daniels, Robert D. ; Bertke, Stephen ; Waters, Kathleen M. ; Schubauer-Berigan, Mary K. Less -
Description:
Objective

To follow-up on earlier studies of the leukaemogenicity of occupational ionising radiation exposure.

Methods

We conducted a nested case-control analysis of leukaemia mortality in a pooled cohort of US nuclear workers followed through 2005. Each case was matched to four controls on attained age. Exposures were estimated from available records. General relative risk models were used to estimate the excess relative risk (ERR) of leukaemia, excluding chronic lymphocytic (CLL), acute myeloid leukaemia, chronic myeloid leukaemia and CLL while controlling for potential confounders. Preferred exposure lags and time-windows of risks were calculated using joint maximum likelihood. Dose-response was also examined using linear, linear-quadratic, categorical and restricted cubic spline models.

Results

There were 369 leukaemia deaths in 105 245 US nuclear workers. The adjusted ERR for non-CLL leukaemia was 0.09 (95% CI −0.17 to 0.65) per 100 mGy. Elevated non-CLL risks were observed from exposures occurring 6–14 years prior to attained age of cases (ERR per 100 mGy=1.9; 95% CI <0 to 8.0). Lagged models indicated non-linearity of risk at very low (<10 mGy) and high (>100 mGy) doses, which contributed to the imprecision of results in linear models. Similar risk attenuation was not evident in time-windows-based models.

Conclusions

Risk estimates were in reasonable agreement with previous estimates, with the temporality of non-CLL leukaemia risk as a dominant factor in dose-response analyses. Future research should focus on methods that improve evaluations of the dose-response, particularly in the low-dose range.


Subjects:
[+]
Case-Control Studies Humans Industry Leukemia Neoplasms, Radiation-Induced Nuclear Reactors Occupational Diseases Occupational Exposure Radiation, Ionizing Radiation Dosage Risk Factors
Source:
Occup Environ Med. 70(1):41-48.
Pubmed ID:
23000827
Pubmed Central ID:
PMC4563861
Document Type:
Journal Article
Funding:
RTD2/Intramural CDC HHS/United States ; Intramural NIH HHS/United States
RTD2/Intramural CDC HHS/United States ; Intramural NIH HHS/United States Less -
Place as Subject:
United States
Main Document Checksum:
[+]
urn:sha256:12957451ac7c10b5fb5dfaa720b9ad9440ba405efdbe709b770602d73adbb94a
Download URL:
https://stacks.cdc.gov/view/cdc/34193/cdc_34193_DS1.pdf
File Type:

Supporting Files

• 	NIHMS717197-supplement-Supp_Data.pdf	pdf
  	nihms717197.nxml	txt
  	nihms717197f1.gif	gif
  	nihms717197f1.jpg	jpeg

More +