Does Autism Diagnosis Age or Symptom Severity Differ Among Children According to Whether Assisted Reproductive Technology was Used to Achieve Pregnancy?

Schieve, Laura A.; Fountain, Christine; Boulet, Sheree L.; Yeargin-Allsopp, Marshalyn; Kissin, Dmitry M.; Jamieson, Denise J.; Rice, Catherine; Bearman, Peter

doi:10.1007/s10803-015-2462-1

i

Does Autism Diagnosis Age or Symptom Severity Differ Among Children According to Whether Assisted Reproductive Technology was Used to Achieve Pregnancy?

Supporting Files

2015
By Schieve, Laura A. ; Fountain, Christine ; Boulet, Sheree L. ; ...

File Language:

English

Details

Alternative Title:

J Autism Dev Disord
Personal Author:

Schieve, Laura A. ; Fountain, Christine ; Boulet, Sheree L. ; Yeargin-Allsopp, Marshalyn ; Kissin, Dmitry M. ; Jamieson, Denise J. ; Rice, Catherine ; Bearman, Peter
Description:

Previous studies report associations between conception with assisted reproductive technology (ART) and autism. Whether these associations reflect an ascertainment or biologic effect is undetermined. We assessed diagnosis age and initial autism symptom severity among >30,000 children with autism from a linkage study of California Department of Developmental Services records, birth records, and the National ART Surveillance System. Median diagnosis age and symptom severity levels were significantly lower for ART-conceived than non-ART-conceived children. After adjustment for differences in the socio-demographic profiles of the two groups, the diagnosis age differentials were greatly attenuated and there were no differences in autism symptomatology. Thus, ascertainment issues related to SES, not ART per se, are likely the driving influence of the differences we initially observed.
Subjects:

Adolescent Autistic Disorder Child Female Humans Male Pregnancy Reproductive Techniques, Assisted
Keywords:

Assisted Reproductive Technology Diagnosis Age Infantile Autism Symptom Severity
Source:

J Autism Dev Disord. 45(9):2991-3003
Pubmed ID:

25997596
Pubmed Central ID:

PMC4553150
Document Type:

Journal Article
Funding:

1 DP1 OD003635-01/OD/NIH HHSUnited States/ ; DP1 OD003635/OD/NIH HHSUnited States/ ; R21 MH096122/MH/NIMH NIH HHSUnited States/ ; CC999999/Intramural CDC HHSUnited States/ ; R21MH096122/MH/NIMH NIH HHSUnited States/
Volume:

45
Issue:

9
Collection(s):

CDC Public Access
Main Document Checksum:

urn:sha-512:21a1c177974b6ea878a96fd9e2e3ff865aaa50cb4afc3411933fc9eeaa3230b59555779fcda1ccaa8d0b7f731a955c89995093072623e0180dc0263ed84eb7d5
Download URL:

https://stacks.cdc.gov/view/cdc/33995/cdc_33995_DS1.pdf
File Type:

[PDF - 536.41 KB ]

File Language:

English

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