Details:

Alternative Title:
BMC Infect Dis
Personal Author:
Jones, James F ; Kulkarni, Prasad S ; Butera, Salvatore T ; Reeves, William C
Jones, James F ; Kulkarni, Prasad S ; Butera, Salvatore T ; Reeves, William C Less -
Description:
Background

Chronic fatigue syndrome (CFS) is an illness in search of an infectious etiology. GB virus-C (GBV-C) virus is a flavivirus with cell tropism and host defense induction qualities compatible with a role in producing the syndrome. The GBV-C genome is detectable in 4% of the population and 12% of the population is seropositive. The present study evaluated the association between infection with GBV and CFS.

Methods

We used a commercial EIA to detect antibodies against the GBV-C E2 protein and a quantitative real-time RT-PCR assay to detect active GBV-C infection. Sera were from a case control study of CFS in Atlanta, Georgia. The Fisher's exact two-tailed test was used for statistical analysis.

Results

Two of 12 CFS patients and one of 21 controls were seropositive for prior GBV-C infection and one control had viral RNA detected, indicating active infection. The results are not statistically different.

Conclusion

We found no evidence that active or past infection with GBV is associated with CFS.


Subject:
[+]
Antibodies, Viral
Case-Control Studies
Fatigue Syndrome, Chronic
Female
Flaviviridae Infections
GB Virus C
Humans
Male
RNA, Viral

Source:
BMC Infect Dis. 2005; 5:78.
Document Type:
Journal Article
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:dcad37eeea3921e80ae5f679df191770556f0cd458f68a9f0554da611c4dc847
File Type:

Supporting Files

• 	1471-2334-5-78.nxml	txt
  	license.txt	txt

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