Integrated cluster- and case-based surveillance for detecting stage III zoonotic pathogens: an example of Nipah virus surveillance in Bangladesh

Details

• Alternative Title:
  Epidemiol Infect
• Personal Author:
  NASER, A. M. ; HOSSAIN, M. J. ; SAZZAD, H. M. S. ; HOMAIRA, N. ; GURLEY, E. S. ; PODDER, G. ; AFROJ, S. ; BANU, S. ; ROLLIN, P. E. ; DASZAK, P. ; AHMED, B.-N. ; RAHMAN, M. ; LUBY, S. P.
• Description:
  This paper explores the utility of cluster- and case-based surveillance established in government hospitals in Bangladesh to detect Nipah virus, a stage III zoonotic pathogen. Physicians listed meningo-encephalitis cases in the 10 surveillance hospitals and identified a cluster when ⩾2 cases who lived within 30 min walking distance of one another developed symptoms within 3 weeks of each other. Physicians collected blood samples from the clustered cases. As part of case-based surveillance, blood was collected from all listed meningo-encephalitis cases in three hospitals during the Nipah season (January-March). An investigation team visited clustered cases' communities to collect epidemiological information and blood from the living cases. We tested serum using Nipah-specific IgM ELISA. Up to September 2011, in 5887 listed cases, we identified 62 clusters comprising 176 encephalitis cases. We collected blood from 127 of these cases. In 10 clusters, we identified a total of 62 Nipah cases: 18 laboratory-confirmed and 34 probable. We identified person-to-person transmission of Nipah virus in four clusters. From case-based surveillance, we identified 23 (4%) Nipah cases. Faced with thousands of encephalitis cases, integrated cluster surveillance allows targeted deployment of investigative resources to detect outbreaks by stage III zoonotic pathogens in resource-limited settings.
• Subjects:
  Adolescent Adult Aged Animals Central Nervous System Protozoal Infections Child Cluster Analysis Disease Outbreaks Female Henipavirus Infections Humans Male Middle Aged Nipah Virus Original Papers Population Surveillance Young Adult Zoonoses

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• Source:
  Epidemiol Infect. 2014; 143(9):1922-1930.
• Pubmed ID:
  25342551
• Pubmed Central ID:
  PMC4456770
• Document Type:
  Journal Article
• Funding:
  07-015-0712-52200/PHS HHS/United States ; 2R01-TW005869/TW/FIC NIH HHS/United States ; 5U01CI000628-01/CI/NCPDCID CDC HHS/United States
• Place as Subject:
  Bangladesh
• Volume:
  143
• Issue:
  9
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:5d00236613957dd2f8fb800d14a2f7b79b36382309597c2a2d3518b0401956be
• Download URL:
  https://stacks.cdc.gov/view/cdc/33957/cdc_33957_DS1.pdf
• File Type:
  [PDF - 292.94 KB ]