Respiratory manganese particle size, time-course and neurobehavioral outcomes in workers at a manganese alloy production plant

Details

• Alternative Title:
  Neurotoxicology
• Personal Author:
  Park, Robert M. ; Bouchard, Maryse F. ; Baldwin, Mary ; Bowler, Rosemarie ; Mergler, Donna
• Description:
  The progression of manganism with chronic exposure to airborne manganese (Mn) is not well understood. Here, we further investigate the findings on exposure and neurobehavioral outcomes of workers from a silico- and ferromanganese production plant and non-exposed workers from the same community in 1990 and 2004, using a variety of exposure metrics that distinguish particle size and origin within the range of respirable airborne exposures. Mn exposure matrices for large respirable particulate (Mn-LRP, dust) and small respirable particulate (Mn-SRP, fume), based on process origins, were used together with detailed work histories since 1973 (plant opening), to construct exposure metrics including burdens and cumulative burdens with various clearance half-lives. For three out of eight 1990 neurobehavioral tests analyzed with linear regression models, duration of Mn exposure was the best predictor: Luria-Nebraska Neuropsychological Battery - Motor Scale, Trail-Making B and Finger Tapping. The Luria-Nebraska Motor Scale had the strongest association (t ∼ 5.0, p < 10(-6)). For outcomes on three other tests, the duration and Mn-SRP metrics were comparable: Trail Making Test A, Cancellation H and Stroop Color-Word Test (color/word subtest). Delayed Word Recall was best predicted by Mn-SRP (based on square root or truncated air-concentrations). The Word score on the Stroop Color-Word Test was the only outcome for which Mn-LRP was the leading predictor (t = -2.92, p = 0.003), while performance on the WAIS-R Digit Span Test was not significantly predicted by any metric. For outcomes evaluated in both 1990 and 2004, a mixed-effect linear regression model was used to examine estimates of within-individual trends. Duration and Mn-SRP were associated with performance on the Luria-Nebraska Motor Scale, as well as with other outcomes that appeared to have both reversible and progressive features, including Trail Making A and B, Cancellation H and Delayed Word Recall. With the mixed-effect model, Digit Span exhibited a significant irreversible association with exposure duration (t = -2.34, p = 0.021) and Mn-SRP (square root; t = -2.38, p = 0.019) metrics. The strong prediction using duration of exposure is consistent with effective homeostatic regulation of tissue-level Mn in the observed exposure range of respirable Mn (< 0.2mg/m(3)).
• Subjects:
  Adult Air Pollutants, Occupational Article Burden Fume Half-life Homeostasis Humans Iron Manganese Manganese Poisoning Middle Aged Neuropsychological Tests Occupational Exposure Particulate Matter Time Factors

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• Source:
  Neurotoxicology. 45:276-284.
• Pubmed ID:
  24721790
• Pubmed Central ID:
  PMC4552041
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States
• Volume:
  45
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:65365a6f83049a60baab60a06d0d15efe1f71e76ee79ee9bdd23dfd703c9e34b
• Download URL:
  https://stacks.cdc.gov/view/cdc/33917/cdc_33917_DS1.pdf
• File Type:
  [PDF - 618.12 KB ]