Effect of topical vaginal products on the detection of prostate-specific antigen, a biomarker of semen exposure, using ABAcards☆,☆☆

Snead, Margaret C.; Kourtis, Athena P.; Black, Carolyn M.; Mauck, Christine K.; Brown, Teresa M.; Penman-Aguilar, Ana; Melendez, Johan H.; Gallo, Maria F.; Jamieson, Denise J.; Macaluso, Maurizio

doi:10.1016/j.contraception.2012.10.034

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CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners. As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.

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Effect of topical vaginal products on the detection of prostate-specific antigen, a biomarker of semen exposure, using ABAcards☆,☆☆

Dec 04 2012
By Snead, Margaret C. ; Kourtis, Athena P. ; Black, Carolyn M. ; ...
http://dx.doi.org/10.1016/j.contraception.2012.10.034
Source: Contraception. 88(3):382-386.

[PDF-568.70 KB]

English

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Details:

Alternative Title:

Contraception
Personal Author:

Snead, Margaret C. ; Kourtis, Athena P. ; Black, Carolyn M. ; Mauck, Christine K. ; Brown, Teresa M. ; ... More +

Snead, Margaret C. ; Kourtis, Athena P. ; Black, Carolyn M. ; Mauck, Christine K. ; Brown, Teresa M. ; Penman-Aguilar, Ana ; Melendez, Johan H. ; Gallo, Maria F. ; Jamieson, Denise J. ; Macaluso, Maurizio Less -
Description:

Background

Prostate-specific antigen (PSA) is a biomarker of recent semen exposure. There is currently only limited information on whether topical vaginal products affect PSA assays. We investigated this question using various dilutions of several vaginal products (lubricants and spermicides) and the Abacus ABAcard for PSA detection.

Study Design

Pooled semen controls and various dilutions of nonoxynol-9 (N9), carboxymethyl cellulose (CMC), Replens, Gynol 2, K-Y jelly, Astroglide, Surgilube, combined with pooled semen dilutions, were tested for PSA using the Abacus ABAcard.

Results

N9 (2% with saline) and CMC did not appear to affect the results of testing with the ABAcard, but not all semen dilutions were tested. The other products (including Replens and Gynol, which is 2% N9 with propylene glycol, K-Y, Astroglide and Surgilube) at some of the dilutions tested either affected or gave invalid results with PSA testing using the ABAcard. Both Gynol 2 and K-Y at 1:10 dilution gave false-positive results.

Conclusions

Some vaginal products affect PSA results obtained by using the semiquantitative ABAcard. In vivo confirmation is necessary to further optimize PSA detection when topical vaginal products are present.
Subjects:

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Biomarkers Cellulose False Negative Reactions False Positive Reactions Female Glycerol Humans Male Phosphates Propylene Glycols Prostate-Specific Antigen Spermatocidal Agents Vagina Vaginal Creams, Foams, And Jellies
Source:

Contraception. 88(3):382-386.
Pubmed ID:

23218862
Pubmed Central ID:

PMC4547343
Document Type:

Journal Article
Funding:

CC999999/Intramural CDC HHS/United States
Volume:

88
Issue:

3
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:1ce522ccfc5964b3fd107e371804beb3534dece3995ee916b597bb46d4c19019
Download URL:

https://stacks.cdc.gov/view/cdc/33902/cdc_33902_DS1.pdf
File Type:

	nihms715625.nxml	bin
	nihms715625f1.gif	gif
	nihms715625f1.jpg	jpeg

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