Details:

Alternative Title:
Birth Defects Res A Clin Mol Teratol
Publisher's site:
http://dx.doi.org/10.1002/bdra.23096
Personal Author:
Polen, Kara N. D. ; Rasmussen, Sonja A. ; Riehle-Colarusso, Tiffany ; Reefhuis, Jennita
Polen, Kara N. D. ; Rasmussen, Sonja A. ; Riehle-Colarusso, Tiffany ; Reefhuis, Jennita Less -
Corporate Authors:
National Birth Defects Prevention Study
Description:
Background

Few epidemiologic studies have investigated the use of venlafaxine (Effexor®), an antidepressant used to treat major depression and anxiety disorders in adults, during pregnancy. Our objective was to determine whether use of venlafaxine during pregnancy is associated with specific birth defects.

Methods

We used data from the National Birth Defects Prevention Study (NBDPS), a population-based, case-control study in the United States. Our analysis included mothers with pregnancies affected by one of 30 selected birth defects (cases) and babies without birth defects (controls) with estimated dates of delivery between 1997–2007. Exposure was any reported use of venlafaxine from one month preconception through the third month of pregnancy. We calculated adjusted odds ratios (aORs) and 95% Fisher’s Exact confidence intervals (CIs) for 24 birth defect groups for which at least 400 case mothers were interviewed. Our adjusted analyses controlled for maternal age and race-ethnicity.

Results

Among the 27,045 NBDPS participants who met inclusion criteria, 0.17% (14/8,002) of control mothers and 0.40% (77/19,043) of case mothers reported any use of venlafaxine from one month preconception through the third month of pregnancy. Statistically significant associations were found for anencephaly, atrial septal defect (ASD) secundum or ASD not otherwise specified, coarctation of the aorta, cleft palate, and gastroschisis.

Conclusions

Our data suggest associations between periconceptional use of venlafaxine and some birth defects. However, sample sizes were small, confidence intervals were wide, and additional studies are needed to confirm these results.


Subject:
[+]
Abnormalities, Drug-Induced
Adult
Anencephaly
Antidepressants
Antidepressive Agents, Second-Generation
Aortic Coarctation
Article
Birth Defects
Cleft Palate
Cyclohexanols
Epidemiology
Female
Gastroschisis
Heart Septal Defects, Atrial
Humans
Maternal Exposure
Odds Ratio
Pregnancy
Venlafaxine

Source:
Birth Defects Res A Clin Mol Teratol. 97(1):28-35.
Pubmed ID:
23281074
Pubmed Central ID:
PMC4484721
Document Type:
Journal Article
Funding:
FVC1/Intramural CDC HHS/United States
Place as Subject:
United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:487938c5c462b57516b9b9f8d192dff5118f933ee92a74d31d812e47e1c844e2
File Type:

Supporting Files

• 	nihms702822.nxml	txt
  	nihms702822f1.gif	gif
  	nihms702822f1.jpg	jpeg

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