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Family History of Myocardial Infarction Is a Risk Factor for Venous Thromboembolism Among Whites But Not Among Blacks
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2013 Jul-Aug
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Source: Clin Appl Thromb Hemost. 2012; 19(4):410-417
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Alternative Title:Clin Appl Thromb Hemost
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Description:In addition to potentially sharing common pathogenesis and clinical manifestations, venous and arterial thromboses might have overlapping risk factors. To evaluate the family history of myocardial infarction (MI) as a risk factor for venous thromboembolism (VTE) among whites and blacks, we analyze data from the Genetic Attributes and Thrombosis Epidemiology (GATE) study. Results indicate that the association between VTE and a family history of MI is statistically significant only among whites (odds ratio [OR] = 1.3; 95% confidence interval [CI] = 1.03-1.8), particularly when they have diabetes mellitus (OR = 3.1; 95% CI = 1.2-8.0). Among blacks, the association between VTE and a family history of MI is not statistically significant (OR = 1.2; 95% CI = 0.89-1.5) either among those with diabetes or those without diabetes. We conclude that a family history of MI is a risk factor for VTE among certain populations stratified by race and comorbid conditions.
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Pubmed ID:22696590
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Pubmed Central ID:PMC4480676
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