Is Maternal Parity an Independent Risk Factor for Birth Defects?

Details

• Alternative Title:
  Birth Defects Res A Clin Mol Teratol
• Personal Author:
  Duong, Hao T. ; Hoyt, Adrienne T. ; Carmichael, Suzan L. ; Gilboa, Suzanne M. ; Canfield, Mark A. ; Case, Amy ; McNeese, Melanie L. ; Waller, Dorothy Kim
• Corporate Authors:
  National Birth Defects Prevention Study
• Description:
  BACKGROUND
  
  Although associations between maternal parity and birth defects have been observed previously, few studies have focused on the possibility that parity is an independent risk factor for birth defects. We investigated the relation between levels of parity and a range of birth defects, adjusting each defect group for the same covariates.
  
  METHODS
  
  We included infants who had an estimated delivery date between 1997 and 2007 and participated in the National Birth Defects Prevention Study, a multisite case-control study. Cases included infants or fetuses belonging to 38 phenotypes of birth defects (n = 17,908), and controls included infants who were unaffected by a major birth defect (n = 7173). Odds ratios (ORs) were adjusted for 12 covariates using logistic regression.
  
  RESULTS
  
  Compared with primiparous mothers, nulliparous mothers were more likely to have infants with amniotic band sequence, hydrocephaly, esophageal atresia, hypospadias, limb reduction deficiencies, diaphragmatic hernia, omphalocele, gastroschisis, tetralogy of Fallot, and septal cardiac defects, with significant ORs (1.2 to 2.3). Compared with primiparous mothers, multiparous mothers had a significantly increased risk of omphalocele, with an OR of 1.5, but had significantly decreased risk of hypospadias and limb reduction deficiencies, with ORs of 0.77 and 0.77.
  
  CONCLUSIONS
  
  Nulliparity was associated with an increased risk of specific phenotypes of birth defects. Most of the phenotypes associated with nulliparity in this study were consistent with those identified by previous studies. Research into biologic or environmental factors that are associated with nulliparity may be helpful in explaining some or all of these associations.
  
  
• Subjects:
  Adult Case-Control Studies Congenital Abnormalities Female Heart Defects, Congenital Hernia, Umbilical Humans Odds Ratio Parity Phenotype Pregnancy Pregnancy Complications Risk Factors Young Adult

  More +
• Source:
  Birth Defects Res A Clin Mol Teratol. 2012; 94(4):230-236.
• Pubmed ID:
  22371332
• Pubmed Central ID:
  PMC4476024
• Document Type:
  Journal Article
• Funding:
  5U01DD000494/DD/NCBDD CDC HHS/United States ; SUZ0/Intramural CDC HHS/United States
• Volume:
  94
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:ae0cedb580bb96a6e74fc7e56ee75dd6055252d9ea064237818c9771644c99b645dc768d915a0318299e82d2aabe29500af99e93a8026f337014818987c14fc9
• Download URL:
  https://stacks.cdc.gov/view/cdc/33788/cdc_33788_DS1.pdf
• File Type:
  [PDF - 227.05 KB ]