Transferrin Saturation and Hospital Length of Stay and Mortality in Medicare Beneficiaries

Details

• Alternative Title:
  J Am Geriatr Soc
• Personal Author:
  Mainous, Arch G. ; Diaz, Vanessa A. ; Knoll, Michele E. ; Hulihan, Mary M. ; Grant, Althea M. ; Wright, Robert U.
• Description:
  OBJECTIVES
  
  To evaluate in a large, nationally representative cohort the association between high serum transferrin saturation (TS) and hospital length of stay and mortality in older adults.
  
  DESIGN
  
  Prospective cohort.
  
  SETTING
  
  Longitudinal analyses of the Third National Health and Nutrition Examination Survey linked to Medicare claims from 1991 through 2006.
  
  PARTICIPANTS
  
  Medicare beneficiaries aged 65 and older at baseline.
  
  MEASUREMENTS
  
  Transferrin saturation collected on each participant at baseline was characterized as <20.0%, 20.0% to 54.9%, and 55.0% and greater. Length of stay in the hospital and death in the hospital were primary outcomes. Analyses were adjusted for age, sex, race and ethnicity, education, and severity of illness.
  
  RESULTS
  
  Individuals hospitalized during the study period (79.4%) with high (odds ratio (OR) = 2.54, 95% confidence interval (CI) = 1.05–6.12) or low (OR = 1.31, 95% CI = 1.07–1.62) TS had a significantly greater risk of death than those with moderate TS. Individuals with high TS had longer average length of stay per hospitalization (11.1 days, (standard error, SE 1.7 days), P = .01) than those with moderate TS (8.4 (0.3) days). Individuals with high TS also had more hospital days per year (8.6 (2.0) days, P = .04) than those with moderate TS (6.7 (0.5) days).
  
  CONCLUSION
  
  High TS is associated with longer length of stay and death in the hospital (unweighted N = 3,847, weighted N = 28,395,464).
  
  
• Subjects:
  Aged Chronic Disease Female Follow-Up Studies Hemochromatosis Hospital Mortality Hospitals Humans Length Of Stay Male Nutrition Surveys Odds Ratio Prospective Studies Transferrin

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• Source:
  J Am Geriatr Soc. 2012; 61(1):132-136.
• Pubmed ID:
  23205743
• Pubmed Central ID:
  PMC4469174
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States ; MM1144/PHS HHS/United States
• Name as Subject:
  National Health And Nutrition Examination Survey (U.S.)
• Place as Subject:
  United States
• Volume:
  61
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:6d84edc78709a6c3f8cf7e88bd4a7754f4bf94923aaa33a14797573c6e0c797f
• Download URL:
  https://stacks.cdc.gov/view/cdc/33779/cdc_33779_DS1.pdf
• File Type:
  [PDF - 136.73 KB ]