The Study to Explore Early Development (SEED): A Multisite Epidemiologic Study of Autism by the Centers for Autism and Developmental Disabilities Research and Epidemiology (CADDRE) Network

Details

• Alternative Title:
  J Autism Dev Disord
• Personal Author:
  Schendel, Diana ; DiGuiseppi, Carolyn ; Croen, Lisa ; Fallin, M Danielle ; Reed, Philip L. ; Schieve, Laura ; Wiggins, Lisa ; Daniels, Julie ; Grether, Judith ; Levy, Susan ; Miller, Lisa ; Newschaffer, Craig ; Pinto-Martin, Jennifer ; Robinson, Cordelia ; Windham, Gayle ; Alexander, Aimee ; Aylsworth, Arthur ; Bernal, Pilar ; Bonner, Joseph D. ; Blaskey, Lisa ; Bradley, Chyrise ; Collins, Jack ; Ferretti, Casara ; Farzadegan, Homayoon ; Giarelli, Ellen ; Harvey, Marques ; Hepburn, Susan ; Herr, Matthew ; Kaparich, Kristina ; Landa, Rebecca ; Lee, Li-Ching ; Levenseller, Brooke ; Meyerer, Stacey ; Rahbar, Mohammad H. ; Ratchford, Andria ; Reynolds, Ann ; Rosenberg, Steve ; Rusyniak, Julie ; Shapira, Stuart K. ; Smith, Karen ; Souders, Margaret ; AaronThompson, Patrick ; Young, Lisa ; Yeargin-Allsopp, Marshalyn
• Description:
  The Study to Explore Early Development (SEED), a multisite investigation addressing knowledge gaps in autism phenotype and etiology, aims to: (1) characterize the autism behavioral phenotype and associated developmental, medical, and behavioral conditions and (2) investigate genetic and environmental risks with emphasis on immunologic, hormonal, gastrointestinal, and sociodemographic characteristics. SEED uses a case-control design with population-based ascertainment of children aged 2-5 years with an autism spectrum disorder (ASD) and children in two control groups-one from the general population and one with non-ASD developmental problems. Data from parent-completed questionnaires, interviews, clinical evaluations, biospecimen sampling, and medical record abstraction focus on the prenatal and early postnatal periods. SEED is a valuable resource for testing hypotheses regarding ASD characteristics and causes.
• Subjects:
  Autistic Disorder Case-Control Studies Child, Preschool Developmental Disabilities Female Humans Male Parents Phenotype Prevalence Surveys And Questionnaires

  More +
• Source:
  J Autism Dev Disord. 42(10):2121-2140
• Pubmed ID:
  22350336
• Pubmed Central ID:
  PMC4455890
• Document Type:
  Journal Article
• Funding:
  U10DD000184/DD/NCBDD CDC HHSUnited States/ ; U10DD000181/DD/NCBDD CDC HHSUnited States/ ; U01 DD001210/DD/NCBDD CDC HHSUnited States/ ; CC999999/Intramural CDC HHSUnited States/ ; U10DD000182/DD/NCBDD CDC HHSUnited States/ ; U10DD000498/DD/NCBDD CDC HHSUnited States/ ; U10DD000183/DD/NCBDD CDC HHSUnited States/ ; U10DD000180/DD/NCBDD CDC HHSUnited States/
• Volume:
  42
• Issue:
  10
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:8b44eef533b2ccd407b7a95dc24d41cc44ef3c3f7b2f9244a04c3ec0d6c6e6cb
• Download URL:
  https://stacks.cdc.gov/view/cdc/33769/cdc_33769_DS1.pdf
• File Type:
  [PDF - 1.15 MB ]