Details:

Alternative Title:
BJOG
Personal Author:
Kesmodel, Ulrik Schiøler ; Bertrand, Jacquelyn ; Støvring, Henrik ; Skarpness, Bradley ; Denny, Clark H ; ... More +
Kesmodel, Ulrik Schiøler ; Bertrand, Jacquelyn ; Støvring, Henrik ; Skarpness, Bradley ; Denny, Clark H ; Mortensen, Erik Lykke Less -
Corporate Authors:
Lifestyle During Pregnancy Study Group
Description:
Objective

To conduct a combined analysis of the estimated effects of maternal average weekly alcohol consumption and any binge drinking in early to mid-pregnancy on general intelligence, attention, and executive functions in five-year old children.

Design

Follow-up study.

Setting and population

1,628 women and their children sampled from the Danish National Birth Cohort.

Methods

Participants were sampled based on maternal alcohol consumption during early pregnancy. At age five, the children were tested for general intelligence, attention and executive function. The three outcomes were analyzed together in a multivariate model to obtain joint estimates and p-values for the association of alcohol across outcomes. The effects of low-moderate alcohol consumption and binge drinking in early pregnancy were adjusted for a wide range of potential confounders.

Main outcome measures

Wechsler Preschool and Primary Scale of Intelligence-Revised (WPPSI-R), the Test of Everyday Attention for Children at Five (TEACh-5), the Behavior Rating Inventory of Executive Functions (BRIEF).

Results

Multivariate analyses showed no statistically significant effects of average weekly alcohol consumption or any binge drinking, individually or in combination. These results replicate findings from separate analyses of each outcome variable.

Conclusion

The present study contributes comprehensive methodological and statistical approaches that should be incorporated in future studies of low-moderate alcohol consumption and binge drinking during pregnancy. Further, since no safe level of drinking during pregnancy has been established, the most conservative advice for women is not to drink alcohol during pregnancy. However, the present study suggests that small amounts consumed occasionally may not present serious concern.


Subject:
[+]
Adult Alcohol Drinking Article Attention Binge Drinking BRIEF Child, Preschool Denmark Ethanol Executive Function Female Follow-Up Studies Humans Intelligence Low-moderate Alcohol Consumption Male Multiple Outcome Analyses Neurodevelopmental Effects Pregnancy Pregnancy Trimester, First Pregnancy Trimester, Second Prenatal Exposure Delayed Effects Prenatal Exposures TEACh-5 WPPSI-R Executive Function
Source:
BJOG. 119(10):1180-1190
Pubmed ID:
22712700
Pubmed Central ID:
PMC4435537
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:f0b58701dc92275ed9928f70671224ccc2efa436c81e4406c3885d38f94d94a3
Download URL:
https://stacks.cdc.gov/view/cdc/33751/cdc_33751_DS1.pdf
File Type:

Supporting Files

• nihms682995.nxml

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