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The effect of different alcohol drinking patterns in early to mid-pregnancy on child’s intelligence, attention and executive function
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June 20 2012
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Source: BJOG. 119(10):1180-1190
[PDF-309.67 KB]
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Alternative Title:BJOG
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Description:Objective
To conduct a combined analysis of the estimated effects of maternal average weekly alcohol consumption and any binge drinking in early to mid-pregnancy on general intelligence, attention, and executive functions in five-year old children.
Design
Follow-up study.
Setting and population
1,628 women and their children sampled from the Danish National Birth Cohort.
Methods
Participants were sampled based on maternal alcohol consumption during early pregnancy. At age five, the children were tested for general intelligence, attention and executive function. The three outcomes were analyzed together in a multivariate model to obtain joint estimates and p-values for the association of alcohol across outcomes. The effects of low-moderate alcohol consumption and binge drinking in early pregnancy were adjusted for a wide range of potential confounders.
Main outcome measures
Wechsler Preschool and Primary Scale of Intelligence-Revised (WPPSI-R), the Test of Everyday Attention for Children at Five (TEACh-5), the Behavior Rating Inventory of Executive Functions (BRIEF).
Results
Multivariate analyses showed no statistically significant effects of average weekly alcohol consumption or any binge drinking, individually or in combination. These results replicate findings from separate analyses of each outcome variable.
Conclusion
The present study contributes comprehensive methodological and statistical approaches that should be incorporated in future studies of low-moderate alcohol consumption and binge drinking during pregnancy. Further, since no safe level of drinking during pregnancy has been established, the most conservative advice for women is not to drink alcohol during pregnancy. However, the present study suggests that small amounts consumed occasionally may not present serious concern.
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Pubmed ID:22712700
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Pubmed Central ID:PMC4435537
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Volume:119
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Issue:10
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